Too sweet: Problems of protein glycation in the eye.
Too sweet: Problems of protein glycation in the eye.
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DOI：
10.1016/j.exer.2018.08.017
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发表时间：
2019-01
影响因子：
3.4
通讯作者：
Taylor A
中科院分区：
文献类型：
--
作者：
Bejarano E;Taylor A
实验室和流行病学数据表明，高血糖水平和/或高血糖饮食与多种年龄相关疾病有关，包括年龄相关性黄斑变性、白内障、帕金森病、阿尔茨海默病、糖尿病视网膜病变和青光眼。高浓度的血糖和调节血糖的系统的扰动导致晚期糖基化终产物（AGEs）的积累。AGEs是一种有毒化合物，由糖及其代谢产物与生物分子在称为糖化的非酶生化反应中结合形成。在体外和体内的数据表明，高糖消费与AGEs在各种人体组织中的积累。高血压，沿着氧化环境和许多眼组织中有限的细胞增殖，促进AGEs的形成并排除AGEs的稀释和细胞分裂的相关损伤。这些情况使许多眼组织容易受到糖基化衍生的损伤。在这里，我们总结了关于糖基化诱导的眼组织功能障碍及其对眼部疾病的发生和发展的贡献的研究。我们还讨论了如何管理碳水化合物营养可以提供一种低成本的方法来改善AGEs相关疾病的进展，包括年龄相关性黄斑变性和一些白内障，因为他们对心血管疾病和糖尿病。
Laboratory and epidemiological data indicate that high blood sugar levels and/or consuming high glycemia diets are linked to multiple age-related diseases, including age-related macular degeneration, cataract, Parkinson’s disease, Alzheimer’s disease, diabetic retinopathy, and, apparently glaucoma. High concentrations of blood sugar and perturbations of the systems that regulate blood sugar lead to the accumulation of advanced-glycation end products (AGEs). AGEs are toxic compounds that are formed from the combination of sugars and their metabolites with biomolecules in a non-enzymatic biochemical reaction called glycation. In vitro and in vivo data indicate that high sugar consumption is associated with accumulation of AGEs in a variety of human tissues. Hyperglycemia, along with an oxidative environment and limited cell proliferation in many ocular tissues, encourages formation and precludes dilution of AGEs and associated damage by cell division. These circumstances make many eye tissues vulnerable to glycation-derived damage. Here, we summarize research regarding glycation-induced ocular tissue dysfunction and its contribution to the onset and development of eye disorders. We also discuss how management of carbohydrate nutrition may provide a low-cost way to ameliorate the progression of AGEs-related diseases, including age related macular degeneration and some cataracts, as they do for cardiovascular disease and diabetes.
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影响因子：
4.1
作者：
Albon, J;Karwatowski, WSS;Duance, VC
通讯作者：
Duance, VC
影响因子：
8.2
作者：
Berner, A. K.;Brouwers, O.;Stitt, A. W.
通讯作者：
Stitt, A. W.
影响因子：
7.1
作者：
Chiu, CJ;Hubbard, LD;Taylor, A
通讯作者：
Taylor, A
影响因子：
8.2
作者：
Curtis, T. M.;Hamilton, R.;Stitt, A. W.
通讯作者：
Stitt, A. W.
DOI：
10.1111/j.1432-1033.1995.0408h.x
发表时间：
1995-06-01
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
ARAKI, N;HIGASHI, T;HORIUCHI, S
通讯作者：
HORIUCHI, S