Host/microbiota interactions in health and diseases-Time for mucosal microbiology!

Host/microbiota interactions in health and diseases-Time for mucosal microbiology!
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宿主/微生物群在健康和疾病中的相互作用——黏膜微生物学的时间到了!

DOI:
10.1038/s41385-021-00383-w
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发表时间:
2021-09
期刊:
影响因子:
8
通讯作者:
Chassaing B
Chassaing B
中科院分区:
医学1区
文献类型:
--
作者:
Daniel N;Lécuyer E;Chassaing B

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在过去的20年里,一个新的研究领域描绘了微生物群在健康和疾病中的重要性。不适当的宿主-微生物群相互作用已被证明会引发广泛的慢性炎症性疾病,并定义这种关系扰动背后的确切机制,以及这些扰动可能导致疾病状态的方式,两者都有待充分阐明。粘膜相关微生物群构成了最近研究的与慢性肠道炎症和相关疾病状态的促进密切相关的微生物群体。本文将重点介绍一些开创性的工作,这些工作揭示了粘膜相关微生物群在健康和疾病中的重要性,强调了扩大粘膜微生物学研究领域的挑战和前景。
During the last 20 years, a new field of research delineating the importance of the microbiota in health and diseases has emerged. Inappropriate host-microbiota interactions have been shown to trigger a wide range of chronic inflammatory diseases, and defining the exact mechanisms behind perturbations of such relationship, as well as ways by which these disturbances can lead to disease states, both remain to be fully elucidated. The mucosa-associated microbiota constitutes a recently studied microbial population closely linked with the promotion of chronic intestinal inflammation and associated disease states. This review will highlight seminal works that have brought into light the importance of the mucosa-associated microbiota in health and diseases, emphasizing the challenges and promises of expending the mucosal microbiology field of research.
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