Retinal pigment epithelium development, plasticity, and tissue homeostasis.
Retinal pigment epithelium development, plasticity, and tissue homeostasis.
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DOI：
10.1016/j.exer.2013.09.003
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发表时间：
2014-06
影响因子：
3.4
通讯作者：
Levine, Edward M.
中科院分区：
文献类型：
--
作者：
Fuhrmann, Sabine;Zou, ChangJiang;Levine, Edward M.
关键词：
视网膜色素上皮（RPE）是介于神经视网膜和脉络膜之间的单层上皮。虽然只有1层细胞厚度，但RPE是一个虚拟的主力，在视觉功能和保持邻近组织的结构和生理完整性方面发挥着重要作用。RPE功能缺陷，无论是慢性功能障碍还是年龄相关性下降，都与视网膜退行性疾病包括年龄相关性黄斑变性有关。因此，研究的重点是通过基于干细胞的方法开发替代RPE的技术，主要是因为成熟RPE的再生或自我修复特性似乎有限。尽管如此，RPE细胞具有不同寻常的转分化成各种细胞类型的能力，其特定的命运选择高度依赖于环境。在这篇综述中，我们描述了最近的研究结果，阐明了RPE发展的机制和步骤，并提出了一个发展框架来理解低自我修复能力与高转分化能力之间的明显矛盾。
The retinal pigment epithelium (RPE) is a simple epithelium interposed between the neural retina and the choroid. Although only 1 cell-layer in thickness, the RPE is a virtual workhorse, acting in several capacities that are essential for visual function and preserving the structural and physiological integrities of neighboring tissues. Defects in RPE function, whether through chronic dysfunction or age-related decline, are associated with retinal degenerative diseases including age-related macular degeneration. As such, investigations are focused on developing techniques to replace RPE through stem cell-based methods, motivated primarily because of the seemingly limited regeneration or self-repair properties of mature RPE. Despite this, RPE cells have an unusual capacity to transdifferentiate into various cell types, with the particular fate choices being highly context-dependent. In this review, we describe recent findings elucidating the mechanisms and steps of RPE development and propose a developmental framework for understanding the apparent contradiction in the capacity for low self-repair versus high transdifferentiation.
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影响因子：
2.7
作者：
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通讯作者：
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DOI：
10.1002/jez.a.219
发表时间：
2005-11-01
影响因子：
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通讯作者：
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