Advances in the Role of Endothelial Cells in Cerebral Small Vessel Disease.
Advances in the Role of Endothelial Cells in Cerebral Small Vessel Disease.
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DOI：
10.3389/fneur.2022.861714
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发表时间：
2022
影响因子：
3.4
通讯作者：
中科院分区：
文献类型：
--
作者：
脑小血管病(CSVD)发病率高，严重影响老年患者的生活质量，给社会经济造成严重负担。CSVD的病变主要累及脑小动脉、微动脉、毛细血管和小静脉，通常由多种血管危险因素引起。CSVD在脑磁共振成像(MRI)上通常表现为近期皮质下小梗塞、脑白质高信号、腔隙、脑微出血(CMBS)、血管周围间隙扩大(EPVSS)和脑萎缩。血管内皮细胞(EC)功能障碍早于临床症状。免疫激活、炎症和氧化应激可能是EC损伤的潜在机制。血脑屏障(BBB)的内皮细胞是神经血管单位(NVU)中最重要的部分，它确保血液源源不断地流向大脑。脑血管自我调节受损和血脑屏障紊乱会导致累积性脑损伤。本文就内皮细胞损伤在CSVD中的作用作一综述。此外，还将讨论几种特定的生物标志物，这些标志物可能有助于我们评估内皮功能障碍和探索新的治疗方向。
Cerebral small vessel disease (CSVD) poses a serious socio-economic burden due to its high prevalence and severe impact on the quality of life of elderly patients. Pathological changes in CSVD mainly influence small cerebral arteries, microarteries, capillaries, and small veins, which are usually caused by multiple vascular risk factors. CSVD is often identified on brain magnetic resonance imaging (MRI) by recent small subcortical infarcts, white matter hyperintensities, lacune, cerebral microbleeds (CMBs), enlarged perivascular spaces (ePVSs), and brain atrophy. Endothelial cell (EC) dysfunction is earlier than clinical symptoms. Immune activation, inflammation, and oxidative stress may be potential mechanisms of EC injury. ECs of the blood–brain–barrier (BBB) are the most important part of the neurovascular unit (NVU) that ensures constant blood flow to the brain. Impaired cerebral vascular autoregulation and disrupted BBB cause cumulative brain damage. This review will focus on the role of EC injury in CSVD. Furthermore, several specific biomarkers will be discussed, which may be useful for us to assess the endothelial dysfunction and explore new therapeutic directions.
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DOI：
10.1136/bmj.c3666
发表时间：
2010-07-26
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Debette S;Markus HS
通讯作者：
Markus HS
影响因子：
3.7
作者：
Hu SS;Zhang HG;Zhang QJ;Xiu RJ
通讯作者：
Xiu RJ
影响因子：
9.9
作者：
Arntz, Renate M.;van den Broek, Steffen M. A.;de Leeuw, Frank-Erik
通讯作者：
de Leeuw, Frank-Erik
影响因子：
9.9
作者：
Castello, Juan Pablo;Pasi, Marco;Biffi, Alessandro
通讯作者：
Biffi, Alessandro
DOI：
10.1056/nejmoa1204133
发表时间：
2012-08-30
期刊：
The New England journal of medicine
影响因子：
--
作者：
SPS3 Investigators;Benavente OR;Hart RG;McClure LA;Szychowski JM;Coffey CS;Pearce LA
通讯作者：
Pearce LA