Does the couse of astragalus-containing chinese herbal prescriptions and radiotherapy benefit to non-small-cell lung cancer treatment: a meta-analysis of randomized trials.
Does the couse of astragalus-containing chinese herbal prescriptions and radiotherapy benefit to non-small-cell lung cancer treatment: a meta-analysis of randomized trials.
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DOI：
10.1155/2013/426207
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Zhao Y
中科院分区：
文献类型：
--
作者：
He H;Zhou X;Wang Q;Zhao Y
背景资料。放射治疗已广泛应用于非小细胞肺癌(NSCLC)，但其低疗效和高毒性引起了人们的广泛关注。中国对非小细胞肺癌的治疗多采用黄芪为主的中药方剂和放射治疗，但未对其疗效进行系统分析。目标。目的：评价含黄芪中药方剂配合放疗治疗非小细胞肺癌的疗效。方法：研究方法。检索含黄芪中药方剂联合放射治疗非小细胞肺癌的随机对照试验。使用Review Manager 5.1软件进行数据分析。采用漏斗图和Egger‘s检验评价发表偏倚。结果。29项符合条件的研究符合我们的标准。在这些研究中，分别有8、6和4人报告一年、两年和三年的死亡风险降低。26项研究揭示了肿瘤反应的修正。六项研究表明，卡诺夫斯基的表现状况有所改善。在这些研究中，14项和18项分别显示出白细胞(WBC)毒性降低和放射性肺炎缓解。结论。含黄芪中药方剂配合放疗可提高非小细胞肺癌的疗效，减少放疗的不良反应，从而使患者受益。为了确认确切的优点，进一步严格设计的试验是有必要的。
Background. Radiotherapy has been widely used for non-small-cell lung cancer (NSCLC), while its low efficacy and high toxicity raise big concerns. Astragalus (as a monarch drug)-containing Chinese herbal prescriptions and radiotherapy were frequently coused for NSCLC in China; however, the effects were not systematically analyzed. Objective. To evaluate the benefits of Astragalus-containing Chinese herbal prescriptions combined with radiotherapy for NSCLC. Methods. The randomized controlled trials involving NSCLC treatment with Astragalus-containing Chinese herbal prescriptions combined with radiotherapy were searched. The Review Manager 5.1 software was employed for data analysis. Funnel plot and Egger's test were applied to evaluate publication bias. Results. 29 eligible studies met our criteria. Of the studies, 8, 6, and 4 reported reduced risk of death at one year, two years, and three years, respectively. 26 studies revealed amended tumor response. Six studies showed improved Karnofsky performance status. Among the studies, 14 and 18 displayed a lowered white blood cells (WBC) toxicity and an ameliorated radiation pneumonia, respectively. Conclusion. Couse of Astragalus-containing Chinese herbal prescriptions and radiotherapy may benefit the patients with NSCLC via increasing the therapeutic effectiveness and reducing the toxicity of radiotherapy. To confirm the exact merits, further rigorously designed trials are warranted.
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影响因子：
2.9
作者：
Jia L;Ma S;Hou X;Wang X;Qased AB;Sun X;Liang N;Li H;Yi H;Kong D;Liu X;Fan F
通讯作者：
Fan F
DOI：
10.1038/nrclinonc.2013.64
发表时间：
2013-06
期刊：
Nature reviews. Clinical oncology
影响因子：
--
作者：
Keith RL;Miller YE
通讯作者：
Miller YE
影响因子：
5.6
作者：
Du, Xiaogang;Zhao, Bing;Zeng, Xianyin
通讯作者：
Zeng, Xianyin
影响因子：
2.9
作者：
Block, Keith I;Mead, Mark N
通讯作者：
Mead, Mark N
影响因子：
3.4
作者：
Guo, Li;Bai, Shu-Ping;Wang, Xiao-Hong
通讯作者：
Wang, Xiao-Hong