Ion transport in pigmentation.
Ion transport in pigmentation.
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DOI：
10.1016/j.abb.2014.06.020
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发表时间：
2014-12-01
影响因子：
3.9
通讯作者：
Oancea, Elena V.
中科院分区：
文献类型：
--
作者：
Bellono, Nicholas W.;Oancea, Elena V.
皮肤黑素细胞和眼色素细胞含有称为黑素体的特殊细胞器，负责合成哺乳动物的主要色素黑色素。黑色素合成和调节所涉及的复杂机制的缺陷会导致视力和色素沉着缺陷、视觉系统发育受损以及皮肤癌和眼癌的易感性增加。跨细胞膜的离子传输对于包括色素沉着在内的许多生物过程至关重要，但其调节黑色素合成、储存和转移的分子机制尚不清楚。在这篇综述中，我们首先讨论在黑素细胞质膜上发挥作用的离子通道和转运蛋白；在第二部分中，我们考虑跨细胞内细胞器膜的离子运输，重点是黑素体。我们讨论最近表征的与色素沉着表型相关的溶酶体和内体离子通道和转运蛋白。然后，我们回顾了对色素沉着至关重要的黑素体通道和转运蛋白的证据，讨论了介导其功能的潜在分子机制。研究色素沉着生理学中的离子传输的研究为未来的研究开辟了新的途径，并可能揭示黑素生成背后的新分子机制。
Skin melanocytes and ocular pigment cells contain specialized organelles called melanosomes, which are responsible for the synthesis of melanin, the major pigment in mammals. Defects in the complex mechanisms involved in melanin synthesis and regulation result in vision and pigmentation deficits, impaired development of the visual system,, and increased susceptibility to skin and eye cancers. Ion transport across cellular membranes is critical for many biological processes, including pigmentation, but the molecular mechanisms by which it regulates melanin synthesis, storage, and transfer are not understood. In this review we first discuss ion channels and transporters that function at the plasma membrane of melanocytes; in the second part we consider ion transport across the membrane of intracellular organelles, with emphasis on melanosomes. We discuss recently characterized lysosomal and endosomal ion channels and transporters associated with pigmentation phenotypes. We then review the evidence for melanosomal channels and transporters critical for pigmentation, discussing potential molecular mechanisms mediating their function. The studies investigating ion transport in pigmentation physiology open new avenues for future research and could reveal novel molecular mechanisms underlying melanogenesis.
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DOI：
10.1111/j.1600-0749.1994.tb00068.x
发表时间：
1994-12-01
期刊：
PIGMENT CELL RESEARCH
影响因子：
--
作者：
BRILLIANT, MH;KING, R;NAKATSU, Y
通讯作者：
NAKATSU, Y
影响因子：
9.2
作者：
Daniele, Tiziana;Hurbain, Ilse;Schiaffino, Maria Vittoria
通讯作者：
Schiaffino, Maria Vittoria
影响因子：
3.5
作者：
Ancans, J;Thody, AJ
通讯作者：
Thody, AJ
影响因子：
64.5
作者：
Cang C;Zhou Y;Navarro B;Seo YJ;Aranda K;Shi L;Battaglia-Hsu S;Nissim I;Clapham DE;Ren D
通讯作者：
Ren D
影响因子：
5.5
作者：
Devi, Sulochana;Kedlaya, Rajendra;Setaluri, Vijayasaradhi
通讯作者：
Setaluri, Vijayasaradhi