Acute schizophrenia is accompanied by reduced T cell and increased B cell immunity
Acute schizophrenia is accompanied by reduced T cell and increased B cell immunity
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急性精神分裂症伴有T细胞减少和B细胞免疫力增加
DOI：
10.1007/s00406-010-0098-x
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发表时间：
2010
影响因子：
4.7
通讯作者：
Bogerts B.
中科院分区：
文献类型：
--
作者：
Steiner J;Jacobs R;Panteli B;Brauner M;Schiltz K;Bahn S;Herberth M;Westphal S;Walter M;Bernstein H;Myint AM;Bogerts B.
精神分裂症淋巴细胞分布的先前研究已经产生了不一致的结果，在本研究中进行了总结。基于我们自己的原始数据，可能解释这些变化的潜在混淆进行了分析和讨论。采用流式细胞术检测26例急性偏执型精神分裂症患者和32例健康对照者的外周血CD 3、CD 4、CD 8、CD 19和CD 56表型。治疗6周后，对一个无药物患者亚组进行随访。提供可替宁水平和游离皮质醇指数（FCI），以控制药物、吸烟和压力。可替宁水平与自然杀伤（NK）细胞计数相关（CD 3 −/CD 56+：r=-0.383，P = 0.003），而FCI与B细胞数量相关（CD 19+：r= 0.390，P = 0.003）。考虑到这些协变量，较低水平的T辅助细胞（P= 0.010），降低CD 4/CD 8比值（P= 0.029），和升高B细胞（P= 0.008），发现在急性精神病。用药6周后，在最初未用药的患者中观察到相反的模式：总T细胞（P= 0.005），T辅助细胞（P= 0.003）和T抑制细胞/细胞毒性细胞（P= 0.005）增加，而B细胞计数下降（P= 0.049）。总之，急性偏执型精神分裂症可能伴随着T细胞防御能力降低和向B细胞免疫的转变，这在治疗后恢复正常。除了疾病阶段或亚型和药物治疗外，吸烟和压力也是重要的辅助因素。
Previous studies of lymphocyte distribution in schizophrenia have yielded inconsistent results, as summarized in the present study. Based on our own original data, potential confounds that might explain these variations are analyzed and discussed. Blood samples from 26 patients with acute paranoid schizophrenia were investigated in comparison with 32 matched healthy controls by flow cytometry (CD3, CD4, CD8, CD19, and CD56 phenotyping). A subgroup of drug-free patients was followed up after 6 weeks of treatment. Cotinine levels and the free cortisol index (FCI) were provided in order to control for medication, smoking, and stress. Cotinine levels correlated with natural killer (NK) cell counts (CD3−/CD56+:r= −0.383,P= 0.003) while the FCI was related to B cell numbers (CD19+:r= 0.390,P= 0.003). Considering these covariates, a lower level of T helper cells (P= 0.010), a reduced CD4/CD8 ratio (P= 0.029), and elevated B cells (P= 0.008) were found during acute psychosis. After 6 weeks of medication, an inverse pattern was observed in initially drug-free patients: total T cell (P= 0.005), T helper (P= 0.003), and T suppressor/cytotoxic cells (P= 0.005) increased, while B cell counts declined (P= 0.049). In conclusion, acute paranoid schizophrenia may be accompanied by a reduced T cell defense and a shift towards B cell immunity, which normalizes in response to treatment. In addition to disease stage or subtype and medication, cigarette smoking and stress are important co-factors.
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尼古丁对免疫反应的影响。
影响因子：
4.4
作者：
Yuemei Geng;S. M. Savage;S. Razani;M. Sopori
通讯作者：
M. Sopori
巨细胞病毒和精神分裂症
影响因子：
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作者：
S. Shrikhande;S. Hirsch;J. Coleman;M. Reveley;R. Dayton
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R. Dayton
皮质醇对反复心理社会压力反应的习惯——遗传因素的进一步表征和影响
影响因子：
3.7
作者：
S. Wüst;I. Federenko;E. Rossum;J. Koper;D. Hellhammer
通讯作者：
D. Hellhammer
影响因子：
4.5
作者：
B. Sperner-Unterweger;A. Whitworth;G. Kemmler;W. Hilbe;J. Thaler;G. Weiss;W. Fleischhacker
通讯作者：
B. Sperner-Unterweger;A. Whitworth;G. Kemmler;W. Hilbe;J. Thaler;G. Weiss;W. Fleischhacker
DOI：
10.1124/jpet.302.3.935
发表时间：
2002-09
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Roma Kalra;S. Singh;D. Kracko;S. Matta;B. Sharp;M. Sopori
通讯作者：
Roma Kalra;S. Singh;D. Kracko;S. Matta;B. Sharp;M. Sopori