CXC Chemokines as Therapeutic Targets and Prognostic Biomarkers in Skin Cutaneous Melanoma Microenvironment.
CXC Chemokines as Therapeutic Targets and Prognostic Biomarkers in Skin Cutaneous Melanoma Microenvironment.
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CXC 趋化因子作为皮肤黑色素瘤微环境中的治疗靶点和预后生物标志物
DOI：
10.3389/fonc.2021.619003
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发表时间：
2021
影响因子：
4.7
通讯作者：
Song W
中科院分区：
文献类型：
--
作者：
Zhou X;Peng M;He Y;Peng J;Zhang X;Wang C;Xia X;Song W
皮肤皮肤黑色素瘤(SKCM)是一种由基因激活或突变引起的表皮黑素细胞肿瘤。它是遗传、体质和环境因素相互作用的结果。SKCM具有高度侵袭性，是最具威胁性的皮肤肿瘤。该病发病率逐年上升，是全球皮肤肿瘤死亡的主要原因。肿瘤微环境中的CXC趋化因子可以调节免疫细胞的转运和肿瘤细胞的活性，从而发挥抗肿瘤免疫作用，影响患者的预后。然而，CXC趋化因子在SKCM中的表达水平及其对预后的影响仍不清楚。研究中使用了Oncomine、UALCAN、GEPIA、STRING、GeneMANIA、cBioPortal、Timer、TRRUST、David 6.8和Metasscape。SKCM组织中CXCL1、CXCL5、CXCL8、CXCL9、CXCL10和CXCL13的转录水平显著高于正常组织。CXCL4、CXCL9、CXCL10、CXCL11、CXCL12、CXCL13的表达与SKCM的病理分期密切相关。CXCL4、CXCL9、CXCL10、CXCL11、CXCL13转录水平低的SKCM患者预后较好。CXC趋化因子的差异表达主要与炎症反应、免疫反应和细胞因子介导的信号通路有关。我们的数据表明，CXC趋化因子的关键转录因子是RelA、NF-κB1和Sp1。CXC趋化因子的靶点主要是LCK、Lyn、SYK、MAPK2、MAPK12和ART。在SKCM中，CXC趋化因子的表达与免疫细胞浸润关系密切。我们的研究为筛选SKCM生物标志物、预测预后和选择免疫治疗提供了依据。
Skin Cutaneous Melanoma (SKCM) is a tumor of the epidermal melanocytes induced by gene activation or mutation. It is the result of the interaction between genetic, constitutional, and environmental factors. SKCM is highly aggressive and is the most threatening skin tumor. The incidence of the disease is increasing year by year, and it is the main cause of death in skin tumors around the world. CXC chemokines in the tumor microenvironment can regulate the transport of immune cells and the activity of tumor cells, thus playing an anti-tumor immunological role and affecting the prognosis of patients. However, the expression level of CXC chemokine in SKCM and its effect on prognosis are still unclear. Oncomine, UALCAN, GEPIA, STRING, GeneMANIA, cBioPortal, TIMER, TRRUST, DAVID 6.8, and Metascape were applied in our research. The transcription of CXCL1, CXCL5, CXCL8, CXCL9, CXCL10, and CXCL13 in SKCM tissues were significantly higher than those in normal tissues. The pathological stage of SKCM patients is closely related to the expression of CXCL4, CXCL9, CXCL10, CXCL11, CXCL12, and CXCL13. The prognosis of SKCM patients with low transcription levels of CXCL4, CXCL9, CXCL10, CXCL11, and CXCL13 is better. The differential expression of CXC chemokines is mainly associated with inflammatory response, immune response, and cytokine mediated signaling pathways. Our data indicate that the key transcription factors of CXC chemokines are RELA, NF-κB1 and SP1. The targets of CXC chemokines are mainly LCK, LYN, SYK, MAPK2, MAPK12, and ART. The relationship between CXC chemokine expression and immune cell infiltration in SKCM was closed. Our research provides a basis for screening SKCM biomarkers, predicting prognosis, and choosing immunotherapy.
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影响因子：
7.3
作者：
Gao J;Aksoy BA;Dogrusoz U;Dresdner G;Gross B;Sumer SO;Sun Y;Jacobsen A;Sinha R;Larsson E;Cerami E;Sander C;Schultz N
通讯作者：
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影响因子：
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通讯作者：
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影响因子：
16.6
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