Monte Carlo study of dose distribution improvement by skin-shielding layer design in boron neutron capture therapy for non-small-cell lung cancer

Monte Carlo study of dose distribution improvement by skin-shielding layer design in boron neutron capture therapy for non-small-cell lung cancer
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非小细胞肺癌硼中子俘获疗法中通过皮肤屏蔽层设计改善剂量分布的蒙特卡罗研究

DOI:
10.1051/radiopro/2018024
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发表时间:
2018-06
期刊:
影响因子:
1.1
通讯作者:
Chen D.
Chen D.
中科院分区:
医学4区
文献类型:
--
作者:
Tang X.;Yu H.;Shu D.;Gong C.;Geng C.;Ai Y.;Chen D.

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加速器中子源治疗非小细胞肺癌(NSCLC)硼中子俘获治疗(BNCT)时,皮肤剂量容易超过其剂量限值。针对这一问题,采用蒙特卡罗方法对蒙皮屏蔽方案的材料和厚度进行了设计分析。两种皮肤屏蔽方案更好,可以减少健康器官剂量:方案A(0.1 cm厚的热塑性塑料,富含96%的6 LiF)和方案B(0.6 cm厚的碳酸锂)。照射时间较短的方案B是改善BNCT治疗NSCLC剂量分布的优化方案。
The skin dose exceeds its dose limitation easily in using an accelerator-based neutron source for non-small-cell lung cancer (NSCLC) with boron neutron capture therapy (BNCT). To solve this problem, design analyses in materials and thicknesses of skin-shielding schemes were investigated through Monte Carlo method. Two skin-shielding schemes were better and could reduce the healthy organ dose: scheme A (0.1 cm-thick thermoplastic with 96%-enriched 6LiF), and scheme B (0.6 cm-thick lithium carbonate). Scheme B with shorter irradiation time was the optimized schemes to improve the dose distribution of BNCT for NSCLC.
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