The hypothesis of neuronal interconnectivity as a function of brain size-a general organization principle of the human connectome.
The hypothesis of neuronal interconnectivity as a function of brain size-a general organization principle of the human connectome.
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DOI：
10.3389/fnhum.2014.00915
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发表时间：
2014
影响因子：
2.9
通讯作者：
Jäncke L
中科院分区：
文献类型：
--
作者：
Hänggi J;Fövenyi L;Liem F;Meyer M;Jäncke L
20年前，Ringo和他的同事提出，相对于较小的大脑，在较大的大脑中保持绝对连接在计算上是低效的，因为跨胼胝体信息传递的传导延迟增加了，而且相对于建立这些额外连接所需的大脑质量来说，成本很高。因此，他们假设，较大的大脑在半球内的连接相对较强，而较小的大脑在半球间的连接相对较强，从而导致较大的大脑更强的功能侧化。我们使用基于弥散张量成像的纤维束图术研究了138个大小人脑的神经元互连。我们发现大脑大小和连接类型之间存在显著的相互作用。较大的大脑中，结构内半球连通性更强，而与较小的大脑相比，较大的大脑中半球间连通性仅略微增加。虽然大脑大小和性别是混淆的，但这种影响是与性别无关的。此外，半球间和半球内连接的比例与大脑大小成反比。神经元互联性是大脑大小的一个功能，这一假设可能解释了女性大脑半球间转移时间更短、更对称的原因，也解释了男性视觉和听觉处理偏侧性更强的经验证据。该假设还表明，大脑半球间和半球内连通性的差异是由大脑大小而非性别驱动的，这一发现与最近发表的一项研究相矛盾。我们的发现也与一个区域越不对称，半球间连接密度越小，但半球内连接密度越大的观点相一致。这一假说代表了人类连接组的组织原则，正如我们的跨物种比较所表明的那样，这一原则也可能适用于非人类动物。
Twenty years ago, Ringo and colleagues proposed that maintaining absolute connectivity in larger compared with smaller brains is computationally inefficient due to increased conduction delays in transcallosal information transfer and expensive with respect to the brain mass needed to establish these additional connections. Therefore, they postulated that larger brains are relatively stronger connected intrahemispherically and smaller brains interhemispherically, resulting in stronger functional lateralization in larger brains. We investigated neuronal interconnections in 138 large and small human brains using diffusion tensor imaging-based fiber tractography. We found a significant interaction between brain size and the type of connectivity. Structural intrahemispheric connectivity is stronger in larger brains, whereas interhemispheric connectivity is only marginally increased in larger compared with smaller brains. Although brain size and gender are confounded, this effect is gender-independent. Additionally, the ratio of interhemispheric to intrahemispheric connectivity correlates inversely with brain size. The hypothesis of neuronal interconnectivity as a function of brain size might account for shorter and more symmetrical interhemispheric transfer times in women and for empirical evidence that visual and auditory processing are stronger lateralized in men. The hypothesis additionally shows that differences in interhemispheric and intrahemispheric connectivity are driven by brain size and not by gender, a finding contradicting a recently published study. Our findings are also compatible with the idea that the more asymmetric a region is, the smaller the density of interhemispheric connections, but the larger the density of intrahemispheric connections. The hypothesis represents an organization principle of the human connectome that might be applied also to non-human animals as suggested by our cross-species comparison.
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通讯作者：
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DOI：
10.1080/01688639408402653
发表时间：
1994-06-01
影响因子：
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作者：
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通讯作者：
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