SARS-CoV-2 infection drives an inflammatory response in human adipose tissue through infection of adipocytes and macrophages.
SARS-CoV-2 infection drives an inflammatory response in human adipose tissue through infection of adipocytes and macrophages.
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DOI：
10.1126/scitranslmed.abm9151
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发表时间：
2022-12-07
影响因子：
17.1
通讯作者：
McLaughlin, Tracey L.
中科院分区：
文献类型：
--
作者：
Martinez-Colon, Giovanny J.;Ratnasiri, Kalani;Chen, Heping;Jiang, Sizun;Zanley, Elizabeth;Rustagi, Arjun;Verma, Renu;Chen, Han;Andrews, Jason R.;Mertz, Kirsten D.;Tzankov, Alexandar;Azagury, Dan;Boyd, Jack;Nolan, Garry P.;Schuerch, Christian M.;Matter, Matthias S.;Blish, Catherine A.;McLaughlin, Tracey L.
肥胖的特征是脂肪组织的慢性低度炎症，与2019年冠状病毒病(新冠肺炎)的不良结局有关，但其潜在机制尚不清楚。为探讨脂肪组织感染严重急性呼吸综合征冠状病毒(SARS-CoV-2)是否在发病机制中的作用，我们对新冠肺炎尸检病例进行了评估，并在体外深入分析了脂肪组织对SARS-CoV-2感染的反应。在新冠肺炎尸检病例中，我们在脂肪细胞中发现了SARS-CoV-2RNA，并发现了相关的炎性浸润物。我们确定了两个不同的感染细胞靶点：脂肪细胞和炎性脂肪组织驻留的巨噬细胞亚群。成熟的脂肪细胞对SARS-CoV-2感染是允许的；虽然巨噬细胞被流产感染，但SARS-CoV-2在感染的巨噬细胞和旁观者前脂肪细胞内都启动了炎症反应。这些数据表明，脂肪组织中的SARS-CoV-2感染可能通过在脂肪细胞内复制病毒，以及通过感染脂肪组织驻留的巨噬细胞诱导局部和全身炎症，从而导致新冠肺炎的严重程度。SARS-CoV-2能够感染人类脂肪组织并推动炎症。
Obesity, characterized by chronic low-grade inflammation of the adipose tissue, is associated with adverse coronavirus disease 2019 (COVID-19) outcomes, yet the underlying mechanism is unknown. To explore whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of adipose tissue contributes to pathogenesis, we evaluated COVID-19 autopsy cases and deeply profiled the response of adipose tissue to SARS-CoV-2 infection in vitro. In COVID-19 autopsy cases, we identified SARS-CoV-2 RNA in adipocytes with an associated inflammatory infiltrate. We identified two distinct cellular targets of infection: adipocytes and a subset of inflammatory adipose tissue-resident macrophages. Mature adipocytes were permissive to SARS-CoV-2 infection; although macrophages were abortively infected, SARS-CoV-2 initiated inflammatory responses within both the infected macrophages and bystander preadipocytes. These data suggest that SARS-CoV-2 infection of adipose tissue could contribute to COVID-19 severity through replication of virus within adipocytes and through induction of local and systemic inflammation driven by infection of adipose tissue-resident macrophages. SARS-CoV-2 is capable of infecting human adipose tissue and drives inflammation.
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影响因子：
2.3
作者：
Acet Ozturk, Nilufer Aylin;Ursavas, Ahmet;Karadag, Mehmet
通讯作者：
Karadag, Mehmet
IP-10 和 MCP-1 作为与 COVID-19 疾病严重程度相关的生物标志物。
DOI：
10.1186/s10020-020-00230-x
发表时间：
2020-10-29
期刊：
Molecular medicine (Cambridge, Mass.)
影响因子：
--
作者：
Chen Y;Wang J;Liu C;Su L;Zhang D;Fan J;Yang Y;Xiao M;Xie J;Xu Y;Li Y;Zhang S
通讯作者：
Zhang S
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
7.4
作者：
Blot M;Bour JB;Quenot JP;Bourredjem A;Nguyen M;Guy J;Monier S;Georges M;Large A;Dargent A;Guilhem A;Mouries-Martin S;Barben J;Bouhemad B;Charles PE;Chavanet P;Binquet C;Piroth L;LYMPHONIE study group
通讯作者：
LYMPHONIE study group
DOI：
10.1038/s41366-021-00984-2
发表时间：
2022-01
期刊：
International journal of obesity (2005)
影响因子：
--
作者：
Bellae Papannarao J;Schwenke DO;Manning P;Katare R
通讯作者：
Katare R