Multidimensional study of cell division cycle-associated proteins with prognostic value in gastric carcinoma.
Multidimensional study of cell division cycle-associated proteins with prognostic value in gastric carcinoma.
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DOI：
10.17305/bjbms.2021.5783
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发表时间：
2022-02-01
影响因子：
3.4
通讯作者：
Yu B
中科院分区：
文献类型：
--
作者：
Lu P;Cheng W;Fang K;Yu B
胃癌（GC）是一种普遍存在的恶性肿瘤，预后较差。因此，发现可靠的生物标志物是必要的。细胞分裂周期相关蛋白 (CDCA) 家族由 CDCA1-8 组成，在肿瘤进展中发挥着关键作用。然而，CDCA表达在GC，特别是胃腺癌（STAD）中是否具有预后价值尚未阐明。因此，我们使用生物信息学工具进行了一项多方面的研究，旨在探索 CDCA 表达水平并评估其在 STAD 患者中的潜在预后价值。与健康组织相比，所有八种 CDCA 在 STAD 组织中均显着上调。 CDCA4/7/8 mRNA 表达升高预示总生存期较短，CDCA7 转录水平升高则预示无病生存期较短。 STAD 患者最常见的改变是低 mRNA 表达。结合基因本体论（GO）和京都基因和基因组百科全书（KEGG）途径的功能富集分析表明，细胞周期、foxO信号通路和Epstein-Barr病毒与CDCA的主要功能相关。最后，免疫浸润分析揭示了CDCA表达与六种免疫细胞的浸润程度之间存在显着相关性。因此，差异表达的CDCA可能代表STAD患者预后的潜在生物标志物，可以提高生存率。此外，这项研究可能为免疫治疗药物的设计和开发提供新思路。
Gastric cancer (GC) represents a widespread malignancy with a poor prognosis. Hence, discovering reliable biomarkers is necessary. The cell division cycle-associated protein (CDCA) family, comprising CDCA1–8, plays a key role in tumor progression. However, whether CDCA expression has prognostic value in GC, especially stomach adenocarcinoma (STAD), has not been elucidated yet. Consequently, we conducted a multifaceted study using bioinformatic tools aimed at exploring CDCA expression levels and appraising their potential prognostic values in patients with STAD. All eight CDCAs were significantly upregulated in STAD tissues compared with healthy tissues. Elevated CDCA4/7/8 mRNA expression predicted a short overall survival, and increased CDCA7 transcriptional levels predicted a short disease-free survival. The most frequent alteration in patients with STAD was low mRNA expression. The functional enrichment analysis incorporating the gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) pathways showed that the cell cycle, foxO signaling pathway, and Epstein–Barr virus were relevant to the main functions of CDCAs. Finally, the immune infiltration analysis revealed a significant correlation between CDCA expression and the infiltration extent of six immunocytes. Therefore, differentially expressed CDCAs may represent potential biomarkers for the prognosis of patients with STAD that can improve survival. Furthermore, this study might offer new ideas for the design and development of immunotherapeutic drugs.
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影响因子：
7.3
作者：
Gao J;Aksoy BA;Dogrusoz U;Dresdner G;Gross B;Sumer SO;Sun Y;Jacobsen A;Sinha R;Larsson E;Cerami E;Sander C;Schultz N
通讯作者：
Schultz N
影响因子：
--
作者：
Chen, Chongxiang;Chen, Siliang;Li, Huan
通讯作者：
Li, Huan
影响因子：
39.3
作者：
Ding Z;Li Q;Zhang R;Xie L;Shu Y;Gao S;Wang P;Su X;Qin Y;Wang Y;Fang J;Zhu Z;Xia X;Wei G;Wang H;Qian H;Guo X;Gao Z;Wang Y;Wei Y;Xu Q;Xu H;Yang L
通讯作者：
Yang L
DOI：
10.18632/aging.202260
发表时间：
2020-12-22
期刊：
Aging
影响因子：
--
作者：
Heitor da Silva Maués J;Ferreira Ribeiro H;de Maria Maués Sacramento R;Maia de Sousa R;Pereira de Tommaso R;Dourado Kovacs Machado Costa B;Cardoso Soares P;Pimentel Assumpção P;de Fátima Aquino Moreira-Nunes C;Mário Rodriguez Burbano R
通讯作者：
Mário Rodriguez Burbano R
影响因子：
4.8
作者：
Hayashi, Reiko;Goto, Yuya;Yoshida, Kenichi
通讯作者：
Yoshida, Kenichi