Mechanisms of Genetic Exchange Within the Chromosomal Inversions of Drosophila pseudoobscura
Mechanisms of Genetic Exchange Within the Chromosomal Inversions of Drosophila pseudoobscura
复制标题
果蝇染色体倒位中的遗传交换机制
作者：
S. Schaeffer;W. Anderson
我们利用拟暗果蝇的倒位系统来研究基因排列之间的遗传流是如何发生的。在七个位点的核苷酸多态性的模式被用来推断对不同的基因排列之间的基因转换事件。我们估计基因转换区的平均长度为205 bp，平均转换率为3.4 × 10−6，比突变率高出2个数量级。我们没有检测到基因排列的所有组合之间的基因转换事件，即使有足够的核苷酸变异进行检测和足够的机会发生交换。在0.1 Mb的倒位断点内的遗传通量导致更高水平的分化，但在中央倒位区域的分化水平略低。在倒位断裂点的17 kb内没有检测到基因转换事件，这表明在杂合子的重排断裂点附近减少了双链断裂的形成。至少有一种情况下，选择，而不是接近倒位断点是负责减少多态性被确定。
We have used the inversion system of Drosophila pseudoobscura to investigate how genetic flux occurs among the gene arrangements. The patterns of nucleotide polymorphism at seven loci were used to infer gene conversion events between pairs of different gene arrangements. We estimate that the average gene conversion tract length is 205 bp and that the average conversion rate is 3.4 × 10−6, which is 2 orders of magnitude greater than the mutation rate. We did not detect gene conversion events between all combinations of gene arrangements even though there was sufficient nucleotide variation for detection and sufficient opportunity for exchanges to occur. Genetic flux across the inverted chromosome resulted in higher levels of differentiation within 0.1 Mb of inversion breakpoints, but a slightly lower level of differentiation in central inverted regions. No gene conversion events were detected within 17 kb of an inversion breakpoint suggesting that the formation of double-strand breaks is reduced near rearrangement breakpoints in heterozygotes. At least one case where selection rather than proximity to an inversion breakpoint is responsible for reduction in polymorphism was identified.
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通过醇脱氢酶区域的核苷酸序列分析确定果蝇中的基因流估计。
影响因子：
3.3
作者：
Schaeffer,SW;Miller,EL
通讯作者：
Miller,EL
DOI：
10.1073/pnas.91.24.11517
发表时间：
1994-11
影响因子：
11.1
作者：
J. Rozas;M. Aguadé
通讯作者：
J. Rozas;M. Aguadé
区分假暗果蝇 Xdh 基因座遗传变异的控制力。
影响因子：
3.3
作者：
Riley,MA;Hallas,ME;Lewontin,RC
通讯作者：
Lewontin,RC
DOI：
--
发表时间：
--
期刊：
--
影响因子：
--
作者：
通讯作者：
--
影响因子：
7
作者：
Richards, S;Liu, Y;Gibbs, RA
通讯作者：
Gibbs, RA