Exploiting Advanced Hydrogel Technologies to Address Key Challenges in Regenerative Medicine.
Exploiting Advanced Hydrogel Technologies to Address Key Challenges in Regenerative Medicine.
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DOI：
10.1002/adhm.201700939
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发表时间：
2018-04
影响因子：
10
通讯作者：
Gentleman E
中科院分区：
文献类型：
--
作者：
Foyt DA;Norman MDA;Yu TTL;Gentleman E
再生医学旨在解决从修复关节软骨局灶性损伤到防止心肌梗死后病理组织重塑的一系列挑战。水凝胶是由合成或天然衍生聚合物形成的水膨胀网络，正在成为解决这些挑战的重要工具。水凝胶化学的最新进展使研究人员能够创造出可以作为3D离体组织模型的水凝胶，使他们能够通过复制组织的动态和非线性物理特性来探索细胞生物学的基本问题。在3D生物打印等尖端技术的支持下，满载细胞的水凝胶也被开发出来，具有高度控制的组织特异性结构、脉管系统和生物功能，可以共同指导组织修复。此外，先进的原位形成和脱细胞水凝胶越来越多地被用作生物活性化合物的递送载体和介导宿主细胞反应。本文综述了再生医学用水凝胶的设计和制备的研究进展。它还讨论了受控化学如何允许水凝胶中空间和时间相关特性的精确工程，以及这些材料最终如何转化为临床应用。
Regenerative medicine aims to tackle a panoply of challenges from repairing focal damage to articular cartilage to preventing pathological tissue remodeling after myocardial infarction. Hydrogels are water‐swollen networks formed from synthetic or naturally derived polymers and are emerging as important tools to address these challenges. Recent advances in hydrogel chemistries are enabling researchers to create hydrogels that can act as 3D ex vivo tissue models, allowing them to explore fundamental questions in cell biology by replicating tissues' dynamic and nonlinear physical properties. Enabled by cutting edge techniques such as 3D bioprinting, cell‐laden hydrogels are also being developed with highly controlled tissue‐specific architectures, vasculature, and biological functions that together can direct tissue repair. Moreover, advanced in situ forming and acellular hydrogels are increasingly finding use as delivery vehicles for bioactive compounds and in mediating host cell response. Here, advances in the design and fabrication of hydrogels for regenerative medicine are reviewed. It is also addressed how controlled chemistries are allowing for precise engineering of spatial and time‐dependent properties in hydrogels with a look to how these materials will eventually translate to clinical applications.
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影响因子：
16.6
作者：
Chaudhuri O;Gu L;Darnell M;Klumpers D;Bencherif SA;Weaver JC;Huebsch N;Mooney DJ
通讯作者：
Mooney DJ
影响因子：
3.4
作者：
Camci-Unal G;Aubin H;Ahari AF;Bae H;Nichol JW;Khademhosseini A
通讯作者：
Khademhosseini A
影响因子：
5.7
作者：
Balmayor ER;van Griensven M
通讯作者：
van Griensven M
DOI：
10.2147/opth.s80463
发表时间：
2015
期刊：
Clinical ophthalmology (Auckland, N.Z.)
影响因子：
--
作者：
Boyette JR;Pemberton JD;Bonilla-Velez J
通讯作者：
Bonilla-Velez J
影响因子：
41.2
作者：
Chaudhuri O;Gu L;Klumpers D;Darnell M;Bencherif SA;Weaver JC;Huebsch N;Lee HP;Lippens E;Duda GN;Mooney DJ
通讯作者：
Mooney DJ