Assessment of the Field Utility of a Rapid Point-of-Care Test for SARS-CoV-2 Antibodies in a Household Cohort.
Assessment of the Field Utility of a Rapid Point-of-Care Test for SARS-CoV-2 Antibodies in a Household Cohort.
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DOI：
10.4269/ajtmh.21-0592
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发表时间：
2021-11-24
期刊：
影响因子：
--
通讯作者：
Lin JT
中科院分区：
文献类型：
--
作者：
Churiwal M;Lin KD;Khan S;Chhetri S;Muller MS;Tompkins K;Smith J;Litel C;Whittelsey M;Basham C;Rapp T;Cerami C;Premkumar L;Lin JT
用于检测SARS-CoV-2抗体的床旁（POC）测试提供了自然感染或疫苗接种后血清状态的快速评估。我们在参加SARS-CoV-2家庭队列研究的303名参与者中比较了BioMedomics COVID-19 IgM/IgG快速抗体测试与ELISA的现场性能。快速抗体检测很容易实施，在各种现场环境中，14名用户的解释一致。与ELISA法相比，血清阳转的检测滞后5 ~ 10天。然而，对于症状发作后3 - 5周检测的患者，其敏感性为90%（160/177，95%置信区间[CI] 85-94%），特异性为100%（43/43，95% CI 92-100%）。无症状感染者（74% [14/19]，95% CI 49-91%）和感染早期（45% [29/64]，95% CI 33-58%）的敏感性降低。如果使用得当，快速抗体测试提供了一种方便的方法来检测康复期间的症状感染。
Point-of-care (POC) tests to detect SARS-CoV-2 antibodies offer quick assessment of serostatus after natural infection or vaccination. We compared the field performance of the BioMedomics COVID-19 IgM/IgG Rapid Antibody Test against an ELISA in 303 participants enrolled in a SARS-CoV-2 household cohort study. The rapid antibody test was easily implemented with consistent interpretation across 14 users in a variety of field settings. Compared with ELISA, detection of seroconversion lagged by 5 to 10 days. However, it retained a sensitivity of 90% (160/177, 95% confidence interval [CI] 85–94%) and specificity of 100% (43/43, 95% CI 92–100%) for those tested 3 to 5 weeks after symptom onset. Sensitivity was diminished among those with asymptomatic infection (74% [14/19], 95% CI 49–91%) and early in infection (45% [29/64], 95% CI 33–58%). When used appropriately, rapid antibody tests offer a convenient way to detect symptomatic infections during convalescence.
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