Investigation of SARS-CoV-2 infection and associated lesions in exotic and companion animals.
Investigation of SARS-CoV-2 infection and associated lesions in exotic and companion animals.
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外来及伴生动物SARS-CoV-2感染及相关病变的调查。
DOI：
10.1177/03009858211067467
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发表时间：
2022-07
影响因子：
2.4
通讯作者：
中科院分区：
文献类型：
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作者：
记录在案的严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)在外来动物和同伴动物中的自然感染在人类暴露后并不常见。在动物身上记录的那些通常是温和的和自我限制的，被感染的动物很少死亡或被安乐死。通过一项协调的One Health倡议，对来自不同场所的5只动物进行了身体解剖，这些动物与实验室确认感染SARS-CoV-2的人类接触。接触的流行病学证据和确认性实时逆转录聚合酶链式反应检测相结合，确认了3只猫和1只老虎的感染。根据接触的流行病学证据，一只狗是疑似病例，但SARS-CoV-2检测呈阴性。四只动物在暴露后2至12天出现呼吸道临床症状。这只狗患有支气管间质性肺炎，老虎患有支气管肺炎；两只狗都有合胞体样细胞，没有检测到SARS-CoV-2。这3只猫的个体发现包括转移性乳腺癌、先天性肾脏疾病和心肌疾病。根据尸检结果和标准化算法，在任何病例中，SARS-CoV-2感染都不被认为是死亡原因。对有致命后果的动物进行持续监测和尸检将进一步加深我们对动物自然感染SARS-CoV-2以及病毒在病变发展中的潜在作用的了解。
Documented natural infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in exotic and companion animals following human exposures are uncommon. Those documented in animals are typically mild and self-limiting, and infected animals have only infrequently died or been euthanized. Through a coordinated One Health initiative, necropsies were conducted on 5 animals from different premises that were exposed to humans with laboratory-confirmed SARS-CoV-2 infection. The combination of epidemiologic evidence of exposure and confirmatory real-time reverse transcriptase-polymerase chain reaction testing confirmed infection in 3 cats and a tiger. A dog was a suspect case based on epidemiologic evidence of exposure but tested negative for SARS-CoV-2. Four animals had respiratory clinical signs that developed 2 to 12 days after exposure. The dog had bronchointerstitial pneumonia and the tiger had bronchopneumonia; both had syncytial-like cells with no detection of SARS-CoV-2. Individual findings in the 3 cats included metastatic mammary carcinoma, congenital renal disease, and myocardial disease. Based on the necropsy findings and a standardized algorithm, SARS-CoV-2 infection was not considered the cause of death in any of the cases. Continued surveillance and necropsy examination of animals with fatal outcomes will further our understanding of natural SARS-CoV-2 infection in animals and the potential role of the virus in development of lesions.
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DOI：
10.1126/science.abe5901
发表时间：
2021-01-08
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Oude Munnink BB;Sikkema RS;Nieuwenhuijse DF;Molenaar RJ;Munger E;Molenkamp R;van der Spek A;Tolsma P;Rietveld A;Brouwer M;Bouwmeester-Vincken N;Harders F;Hakze-van der Honing R;Wegdam-Blans MCA;Bouwstra RJ;GeurtsvanKessel C;van der Eijk AA;Velkers FC;Smit LAM;Stegeman A;van der Poel WHM;Koopmans MPG
通讯作者：
Koopmans MPG
影响因子：
4.4
作者：
Perisé-Barrios AJ;Tomeo-Martín BD;Gómez-Ochoa P;Delgado-Bonet P;Plaza P;Palau-Concejo P;González J;Ortiz-Díez G;Meléndez-Lazo A;Gentil M;García-Castro J;Barbero-Fernández A
通讯作者：
Barbero-Fernández A
影响因子：
33.9
作者：
Newman, Alexandra;Smith, David;Behravesh, Casey Barton
通讯作者：
Behravesh, Casey Barton
DOI：
10.3390/v13091813
发表时间：
2021-09-12
期刊：
Viruses
影响因子：
--
作者：
Goryoka GW;Cossaboom CM;Gharpure R;Dawson P;Tansey C;Rossow J;Mrotz V;Rooney J;Torchetti M;Loiacono CM;Killian ML;Jenkins-Moore M;Lim A;Poulsen K;Christensen D;Sweet E;Peterson D;Sangster AL;Young EL;Oakeson KF;Taylor D;Price A;Kiphibane T;Klos R;Konkle D;Bhattacharyya S;Dasu T;Chu VT;Lewis NM;Queen K;Zhang J;Uehara A;Dietrich EA;Tong S;Kirking HL;Doty JB;Murrell LS;Spengler JR;Straily A;Wallace R;Barton Behravesh C
通讯作者：
Barton Behravesh C
DOI：
10.1002/vetr.247
发表时间：
2021-04
期刊：
The Veterinary record
影响因子：
--
作者：
Hosie MJ;Epifano I;Herder V;Orton RJ;Stevenson A;Johnson N;MacDonald E;Dunbar D;McDonald M;Howie F;Tennant B;Herrity D;Da Silva Filipe A;Streicker DG;COVID-19 Genomics UK (COG-UK) consortium;Willett BJ;Murcia PR;Jarrett RF;Robertson DL;Weir W
通讯作者：
Weir W