Construction of tantalum/poly(ether imide) coatings on magnesium implants with both corrosion protection and osseointegration properties.
Construction of tantalum/poly(ether imide) coatings on magnesium implants with both corrosion protection and osseointegration properties.
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DOI：
10.1016/j.bioactmat.2020.10.007
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发表时间：
2021-04
影响因子：
18.9
通讯作者：
Jang TS
中科院分区：
文献类型：
--
作者：
Cheon KH;Park C;Kang MH;Kang IG;Lee MK;Lee H;Kim HE;Jung HD;Jang TS
聚（醚酰亚胺）（PEI）已显示出令人满意的防腐能力与良好的附着力强度作为涂层镁（Mg），一个潜在的候选人，可降解的骨科植入材料。然而，其固有的疏水性导致成骨细胞亲和力不足和缺乏骨整合。在这里，我们修改PEI涂层镁植入物的物理和化学性质。将等离子体浸没离子注入技术与直流（DC）磁控溅射相结合以将生物相容性钽（Ta）引入到PEI涂层的表面上。由于加工时间极短（30 s），PEI涂层在此过程中不会受损，保持了其高防腐蚀性能和粘合稳定性。在最上面的PEI表面上的Ta注入层（大约10 nm厚）产生长期的表面亲水性和有利的表面条件，用于前成骨细胞粘附、增殖和分化。此外，在兔股骨研究中，Ta/PEI涂层Mg植入物显示出显著增强的骨组织亲和力和骨整合能力。这些结果表明，Ta/PEI涂层Mg在可生物降解骨科植入物应用中有望实现早期机械固定和长期成功。在WE 43镁合金植入体表面制备了PEI涂层和Ta离子注入涂层。钽包埋PEI涂层提高了镁合金种植体的耐腐蚀性能。PEI涂层的润湿性通过在其顶表面嵌入Ta而增强。Ta包埋的PEI涂层显著改善了体外和体内反应。Ta包埋的PEI涂层Mg非常适合作为可生物降解的骨科植入材料。
Poly(ether imide) (PEI) has shown satisfactory corrosion protection capability with good adhesion strength as a coating for magnesium (Mg), a potential candidate of biodegradable orthopedic implant material. However, its innate hydrophobic property causes insufficient osteoblast affinity and a lack of osseointegration. Herein, we modify the physical and chemical properties of a PEI-coated Mg implant. A plasma immersion ion implantation technique is combined with direct current (DC) magnetron sputtering to introduce biologically compatible tantalum (Ta) onto the surface of the PEI coating. The PEI-coating layer is not damaged during this process owing to the extremely short processing time (30 s), retaining its high corrosion protection property and adhesion stability. The Ta-implanted layer (roughly 10-nm-thick) on the topmost PEI surface generates long-term surface hydrophilicity and favorable surface conditions for pre-osteoblasts to adhere, proliferate, and differentiate. Furthermore, in a rabbit femur study, the Ta/PEI-coated Mg implant demonstrates significantly enhanced bone tissue affinity and osseointegration capability. These results indicate that Ta/PEI-coated Mg is promising for achieving early mechanical fixation and long-term success in biodegradable orthopedic implant applications. PEI coating with subsequent Ta ion implantation was prepared on WE43 Mg alloy implant. The corrosion resistance of Mg alloy implant was improved by Ta embedded PEI coating. The wettability of PEI coating layer was enhanced by embedded Ta on its top-surface. Ta embedded PEI coating significantly improved in vitro and in vivo responses. Ta embedded PEI-coated Mg is highly suitable as a biodegradable orthopedic implant material.
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影响因子：
2.7
作者：
Galow AM;Rebl A;Koczan D;Bonk SM;Baumann W;Gimsa J
通讯作者：
Gimsa J
影响因子：
6.7
作者：
ATANASSOVA, E;DIMITROVA, T;KOPRINAROVA, J
通讯作者：
KOPRINAROVA, J
DOI：
10.1016/j.jmatprotec.2007.06.058
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2008-02-01
影响因子：
6.3
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影响因子：
9.7
作者：
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通讯作者：
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影响因子：
9.7
作者：
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通讯作者：
Bandyopadhyay, Amit