Development and Validation of Web-Based Nomograms to Precisely Predict Survival Outcomes of Non-metastatic Nasopharyngeal Carcinoma in an Endemic Area.
Development and Validation of Web-Based Nomograms to Precisely Predict Survival Outcomes of Non-metastatic Nasopharyngeal Carcinoma in an Endemic Area.
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开发和验证基于网络的列线图以精确预测流行地区非转移性鼻咽癌的生存结果
DOI：
10.4143/crt.2020.899
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发表时间：
2021-07
影响因子：
4.6
通讯作者：
Sun Y
中科院分区：
文献类型：
--
作者：
Yao JJ;Lin L;Gao TS;Zhang WJ;Lawrence WR;Ma J;Sun Y
This study aimed to develop web-based nomograms to precisely predict survival outcomes in patients with non-metastatic nasopharyngeal carcinoma (NPC) in an endemic area. A total of 10,126 patients who underwent radical intensity-modulated radiotherapy at Sun Yat-sen University Cancer Center (SYSUCC) from 2009 to 2015 were analyzed. We assigned patients into a training cohort (SYSUCC-A, n=6,751) and an internal validation cohort (SYSUCC-B, n=3,375) based on computer-generated random numbers. Patients collected from Wuzhou Red Cross Hospital (WZRCH) between 2012 and 2015 were used as the independent external validation cohort (WZRCH, n=450). Concordance index (C-index) was used to determine predictive accuracy and discriminative ability for the nomogram. The web-based clinicopathologic prediction models for predicting survival were based on Cox regression. The C-indexes for SYSUCC-A, SYSUCC-B, and WZRCH cohorts for the established nomograms to predict 3-year overall survival (OS) was 0.736, 0.715, and 0.691. Additionally, C-indexes to predict 3-year distant metastasis-free survival (DMFS) was 0.717, 0.706, and 0.686, disease-free survival (DFS) was 0.713, 0.697, and 0.656, local relapse-free survival was 0.695, 0.684, and 0.652, and regional relapse-free survival was 0.672, 0.650, and 0.616. The calibration plots showed great agreement between nomogram-predicted 3-year survival outcomes and actual 3-year survival outcomes. Moreover, C-indexes of the nomograms for OS, DMFS, and DFS were significantly superior than TNM stage (p < 0.001 for all). These user-friendly nomograms can precisely predict survival endpoints in patients with non-metastatic NPC. They may serve as a useful tool for providing patient counseling and help physicians to make individual follow-up plans.
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影响因子：
4.6
作者：
Jin YN;Zhang WJ;Cai XY;Li MS;Lawrence WR;Wang SY;Mai DM;Du YY;Luo DH;Mo HY
通讯作者：
Mo HY
调强放射治疗时代流行地区鼻咽癌第 8 版 UICC/AJCC 分期系统的验证。
DOI：
10.6004/jnccn.2017.0121
发表时间：
2017-07-01
影响因子：
13.4
作者：
Tang, Ling-Long;Chen, Yu-Pei;Ma, Jun
通讯作者：
Ma, Jun
预测流行区非转移性鼻咽癌患者长期生存的列线图
影响因子：
--
作者：
Zeng Q;Hong MH;Shen LJ;Meng XQ;Guo X;Qian CN;Wu PH;Huang PY
通讯作者：
Huang PY
影响因子：
45.3
作者：
Chua, DTT;Ma, J;Min, HQ
通讯作者：
Min, HQ
影响因子：
5.7
作者：
Sun, Xueming;Su, Shengfa;Lu, Taixiang
通讯作者：
Lu, Taixiang