Altered resting state functional connectivity of the cognitive control network in fibromyalgia and the modulation effect of mind-body intervention.
Altered resting state functional connectivity of the cognitive control network in fibromyalgia and the modulation effect of mind-body intervention.
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DOI：
10.1007/s11682-018-9875-3
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发表时间：
2019-04
影响因子：
3.2
通讯作者：
Wang C
中科院分区：
文献类型：
--
作者：
Kong J;Wolcott E;Wang Z;Jorgenson K;Harvey WF;Tao J;Rones R;Wang C
这项研究检测了纤维肌痛患者与健康对照组相比认知控制网络(CCN)的静息状态功能连接性(RsFC)的变化，以及有效的干预措施，如太极，如何调节CCN的rsFC变化。本研究纳入纤维肌痛患者和相匹配的健康受试者。对纤维肌痛患者在干预前和干预后12周进行扫描。以双侧背外侧前额叶皮质(DLPFC)为种子，探讨CCN的rsFC。对21例患者和20例健康受试者进行数据分析。与健康受试者相比，纤维肌痛患者基线时双侧嘴前扣带回皮质(RACC)和内侧前额叶皮质(MPFC)之间的rsFC增加。太极干预后CCN与rACC/MPFC之间的rsFC进一步增加，并伴随着临床症状的改善。这种rsFC的变化也与修订的纤维肌痛影响问卷(FIQR)总体影响范围的相应变化显著相关。进一步分析显示，太极干预后PAG和海马区的rACC/MPFC rsFC均显著降低。我们的研究表明，纤维肌痛与CCN rsFC的改变有关，有效的治疗可能会通过进一步增加这种改变的rsFC而导致临床改善。阐明这一增强同素过程的机制可能会加深我们对心身干预非药物治疗纤维肌痛的机制的理解，并有助于开发新的疼痛管理方法。
This study examines altered resting state functional connectivity (rsFC) of the cognitive control network (CCN) in fibromyalgia patients as compared to healthy controls, as well as how effective interventions, such as Tai Chi, can modulate the altered rsFC of the CCN. Patients with fibromyalgia and matched healthy subjects were recruited in this study. Fibromyalgia patients were scanned 12 weeks before and after intervention. The bilateral dorsolateral prefrontal cortex (DLPFC) was used as a seed to explore the rsFC of the CCN. Data analysis was conducted with 21 patients and 20 healthy subjects. Compared to healthy subjects, fibromyalgia patients exhibited increased rsFC between the DLPFC and the bilateral rostral anterior cingulate cortex (rACC) and medial prefrontal cortex (MPFC) at baseline. The rsFC between the CCN and rACC/MPFC further increased after Tai Chi intervention, and this increase was accompanied by clinical improvements. This rsFC change was also significantly associated with corresponding changes in the Overall Impact domain of the Revised Fibromyalgia Impact Questionnaire (FIQR). Further analysis showed that the rACC/MPFC rsFC with both the PAG and hippocampus significantly decreased following Tai Chi intervention. Our study suggests that fibromyalgia is associated with altered CCN rsFC and that effective treatment may elicit clinical improvements by further increasing this altered rsFC. Elucidating this mechanism of enhancing the allostasis process may deepen our understanding of the mechanisms underlying mind-body intervention non-pharmacological treatment of fibromyalgia and facilitate the development of new pain management methods.
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影响因子：
7.4
作者：
Kong J;Jensen K;Loiotile R;Cheetham A;Wey HY;Tan Y;Rosen B;Smoller JW;Kaptchuk TJ;Gollub RL
通讯作者：
Gollub RL
DOI：
10.1016/j.nicl.2018.01.021
发表时间：
2018
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Kong J;Wang Z;Leiser J;Minicucci D;Edwards R;Kirsch I;Wasan AD;Lang C;Gerber J;Yu S;Napadow V;Kaptchuk TJ;Gollub RL
通讯作者：
Gollub RL
影响因子：
3.3
作者：
Chen X;Spaeth RB;Freeman SG;Scarborough DM;Hashmi JA;Wey HY;Egorova N;Vangel M;Mao J;Wasan AD;Edwards RR;Gollub RL;Kong J
通讯作者：
Kong J
影响因子：
5.3
作者：
Kuchinad, Anil;Schweinhardt, Petra;Bushnell, M. Catherine
通讯作者：
Bushnell, M. Catherine
DOI：
10.1073/pnas.1312902110
发表时间：
2013-11-12
影响因子：
11.1
作者：
Kucyi, Aaron;Salomons, Tim V.;Davis, Karen D.
通讯作者：
Davis, Karen D.