Brain serotonin receptors and transporters: initiation vs. termination of escalated aggression.
Brain serotonin receptors and transporters: initiation vs. termination of escalated aggression.
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DOI：
10.1007/s00213-010-2000-y
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发表时间：
2011-02
影响因子：
3.4
通讯作者：
Miczek, Klaus A.
中科院分区：
文献类型：
--
作者：
Takahashi, Aki;Quadros, Isabel M.;de Almeida, Rosa M. M.;Miczek, Klaus A.
最近的研究结果表明，5-HT系统受到复杂的调节，因为它与不同类型的攻击有关。我们着重于（1）5-HT的时相性和紧张性变化和（2）攻击性的状态和特征，并强调不同的受体亚型，它们在特定脑区的作用，反馈调节和其他胺，酸和肽的调制。新的药理学工具区分前三个5-HT受体家族及其由GABA、谷氨酸和CRF的调节。中皮质边缘区5-HT 1A、5-HT 1B和5-HT 2A/2C受体的激活，减少了物种典型性和其他攻击行为。相反，在特定条件下，内侧前额叶皮层或隔区的5-HT 1A和5-HT 1B受体激动剂可以增加攻击行为。5-羟色胺转运体的激活主要减少病理性攻击。对攻击性个体的遗传分析已经确定了几种直接影响5-HT系统的分子（例如，Tph 2、5-HT 1B、5-HT转运蛋白、Pet 1、MAOA）或间接（例如，神经肽Y、αCaMKII、NOS、BDNF）。MAOA基因的功能障碍会加剧啮齿动物和人类的病理性攻击，特别是在与特定经历的相互作用中。对5-HT 1家族的自身受体的反馈和通过异源受体的调节在攻击行为的表达中是重要的。5-HT 2家族表达的紧张性增加可能导致攻击性升级，而5-HT 2受体的阶段性增加抑制攻击性行为。5-HT转运蛋白或5-HT合成和代谢限速酶基因的多态性调节攻击性，通常需要与饲养环境的相互作用。
Recent findings have shown a complexly regulated 5-HT system as it is linked to different kinds of aggression. We focus on (1) phasic and tonic changes of 5-HT and (2) state and trait of aggression, and emphasize the different receptor subtypes, their role in specific brain regions, feed-back regulation and modulation by other amines, acids and peptides. New pharmacological tools differentiate the first three 5-HT receptor families and their modulation by GABA, glutamate and CRF. Activation of 5-HT1A, 5-HT1B and 5-HT2A/2C receptors in mesocorticolimbic areas, reduce species-typical and other aggressive behaviors. In contrast, agonists at 5-HT1A and 5-HT1B receptors in the medial prefrontal cortex or septal area can increase aggressive behavior under specific conditions. Activation of serotonin transporters reduce mainly pathological aggression. Genetic analyses of aggressive individuals have identified several molecules that affect the 5-HT system directly (e.g., Tph2, 5-HT1B, 5-HT transporter, Pet1, MAOA) or indirectly (e.g., Neuropeptide Y, αCaMKII, NOS, BDNF). Dysfunction in genes for MAOA escalates pathological aggression in rodents and humans, particularly in interaction with specific experiences. Feedback to autoreceptors of the 5-HT1 family and modulation via heteroreceptors are important in the expression of aggressive behavior. Tonic increase of the 5-HT2 family expression may cause escalated aggression, whereas the phasic increase of 5-HT2 receptors inhibits aggressive behaviors. Polymorphisms in the genes of 5-HT transporters or rate-limiting synthetic and metabolic enzymes of 5-HT modulate aggression, often requiring interaction with the rearing environment.
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影响因子：
3.4
作者：
Bannai, Makoto;Fish, Eric W.;Miczek, Klaus A.
通讯作者：
Miczek, Klaus A.
DOI：
10.1073/pnas.0810793106
发表时间：
2009-06-23
影响因子：
11.1
作者：
Alenina, Natalia;Kikic, Dana;Bader, Michael
通讯作者：
Bader, Michael
影响因子：
3.4
作者：
Alleva, E;Cirulli, F;Panerai, AE
通讯作者：
Panerai, AE
影响因子：
5.6
作者：
Barkan, Tal;Peled, Avi;Rehavi, Moshe
通讯作者：
Rehavi, Moshe
影响因子：
3.6
作者：
BLANCHARD, RJ;HORI, K;HALL, J
通讯作者：
HALL, J