Youthful memory capacity in old brains: anatomic and genetic clues from the Northwestern SuperAging Project.
Youthful memory capacity in old brains: anatomic and genetic clues from the Northwestern SuperAging Project.
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DOI：
10.1162/jocn_a_00300
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发表时间：
2013-01
影响因子：
3.2
通讯作者：
Mesulam MM
中科院分区：
文献类型：
--
作者：
Rogalski EJ;Gefen T;Shi J;Samimi M;Bigio E;Weintraub S;Geula C;Mesulam MM
西北大学超级老龄化项目招募了80岁以上的社区居民，他们在情景记忆测试中表现异常出色。在之前的一份报告中，一小群超级老人被发现在结构MRI上比一组年龄匹配但认知平均的同龄人具有更高的皮质厚度。SuperAgers还显示出一片ACC，其皮质厚度高于50至60岁的年轻认知健康成年人。在额外的分析中，一些超级老年人具有异常低密度的年龄相关的阿尔茨海默病病理学和异常高数量的von Economo神经元在前扣带回。研究还发现，超级老年人的载脂蛋白E ε4等位基因频率低于普通人群。这些初步结果表明，在老年人中可能会遇到高于平均水平的记忆能力。它们还提供了潜在的生物因素的线索，这些生物因素可能促进对与年龄相关的大脑结构和功能退化变化的抵抗。
The Northwestern University SuperAging Project recruits community dwellers over the age of 80 who have unusually high performance on tests of episodic memory. In a previous report, a small cohort of SuperAgers was found to have higher cortical thickness on structural MRI than a group of age-matched but cognitively average peers. SuperAgers also displayed a patch of ACC where cortical thickness was higher than in 50- to 60-year-old younger cognitively healthy adults. In additional analyses, some SuperAgers had unusually low densities of age-related Alzheimer pathology and unusually high numbers of von Economo neurons in the anterior cingulate gyrus. SuperAgers were also found to have a lower frequency of the ε4 allele of apolipoprotein E than the general population. These preliminary results show that above-average memory capacity can be encountered in advanced age. They also offer clues to potential biological factors that may promote resistance to age-related involutional changes in the structure and function of the brain.
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