Effects of Different Feeding Methods on the Structure, Metabolism, and Gas Production of Infant and Toddler Intestinal Flora and Their Mechanisms.
Effects of Different Feeding Methods on the Structure, Metabolism, and Gas Production of Infant and Toddler Intestinal Flora and Their Mechanisms.
复制标题
不同喂养方式对婴幼儿肠道菌群结构、代谢和产气的影响及其机制
DOI：
10.3390/nu14081568
复制
发表时间：
2022-04-09
期刊：
影响因子：
5.9
通讯作者：
Li, Jinjun
中科院分区：
文献类型：
--
作者：
Pi, Xionge;Hua, Hanju;Wu, Qi;Wang, Xiaorong;Wang, Xin;Li, Jinjun
本研究采用体外模拟肠道微生态发酵和类器官模型，评价不同喂养方式对婴幼儿肠道植物群特征和产气量的影响。我们发现，喂养方法会影响婴儿和幼儿的肠道气体和粪便氨的产生。哺乳后期婴儿补充奶粉可促进有益菌的增殖，包括双歧杆菌。添加岩藻糖基乳糖（2′-FL）的培养基中肠道植物群产气量显著低于添加其他碳源的培养基。综上所述，2′-FL可能通过两种机制减少婴幼儿肠道产气：一是不能被肠道有害细菌利用产气;二是通过调节肠上皮致病基因/信号通路的表达，抑制肠道有害细菌在肠粘膜的定植，从而减少肠道产气有害细菌的增殖。
In this study, we evaluated the effects of different feeding methods on the characteristics of intestinal flora and gas production in infants and toddlers by using an in vitro simulated intestinal microecology fermentation and organoid model. We found that the feeding method influences intestinal gas and fecal ammonia production in infants and toddlers. Supplementation with milk powder for infants in the late lactation period could promote the proliferation of beneficial bacteria, including Bifidobacteria. Intestinal flora gas production in a culture medium supplemented with fucosyllactose (2′-FL) was significantly lower than that in media containing other carbon sources. In conclusion, 2′-FL may reduce gas production in infant and toddler guts through two mechanisms: first, it cannot be used by harmful intestinal bacteria to produce gas; second, it can inhibit intestinal mucosa colonization by harmful bacteria by regulating the expression of intestinal epithelial pathogenic genes/signaling pathways, thus reducing the proliferation of gas-producing harmful bacteria in the gut.
登录
查看更多内容
影响因子：
30.3
作者：
Backhed, Fredrik;Roswall, Josefine;Jun, Wang
通讯作者：
Jun, Wang
影响因子：
12.2
作者：
Grech A;Collins CE;Holmes A;Lal R;Duncanson K;Taylor R;Gordon A
通讯作者：
Gordon A
DOI：
10.1111/j.1749-6632.1968.tb19033.x
发表时间：
1968-01-01
影响因子：
5.2
作者：
LEVITT, MD;INGELFINGER, FJ
通讯作者：
INGELFINGER, FJ
影响因子：
29.4
作者：
KIRK, E
通讯作者：
KIRK, E
影响因子：
168.9
作者：
King, TS;Elia, M;Hunter, JO
通讯作者：
Hunter, JO