Maternal exposures and the infant gut microbiome: a systematic review with meta-analysis.
Maternal exposures and the infant gut microbiome: a systematic review with meta-analysis.
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DOI：
10.1080/19490976.2021.1897210
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发表时间：
2021-01
期刊：
影响因子：
12.2
通讯作者：
Gordon A
中科院分区：
文献类型：
--
作者：
Grech A;Collins CE;Holmes A;Lal R;Duncanson K;Taylor R;Gordon A
生命早期，包括肠道微生物组的建立，是生长和发育的关键窗口。影响微生物组的产后因素，包括分娩方式，喂养类型和抗生素暴露已被广泛研究，但关于子宫内暴露对婴儿肠道微生物组组装的影响仍然存在问题。这项系统性综述旨在综合有关出生前暴露的证据，这些证据会影响早期肠道微生物组。在2019年8月检索了五个数据库，以探索与婴儿微生物组相关的孕前或妊娠“暴露”数据。在识别的1，441篇出版物中，纳入了76篇。据报道，影响微生物组组成和多样性的因素包括母体抗生素和益生菌的使用、饮食摄入、孕前体重指数（BMI）、妊娠期体重增加（GWG）、糖尿病、情绪等。11项研究促成了3项荟萃分析，量化了产妇分娩期抗生素暴露（IAP），BMI和GWG与婴儿微生物组α多样性（香农指数）之间的关联。IAP，母亲超重/肥胖和过度GWG都与减少多样性。大多数研究是观察性的，很少包括早期招募或纵向随访，粪便采样和分析的时间，频率和方法是可变的。标准化和协作对于加强对这一复杂和快速发展领域的理解至关重要。
Early life, including the establishment of the intestinal microbiome, represents a critical window of growth and development. Postnatal factors affecting the microbiome, including mode of delivery, feeding type, and antibiotic exposure have been widely investigated, but questions remain regarding the influence of exposures in utero on infant gut microbiome assembly. This systematic review aimed to synthesize evidence on exposures before birth, which affect the early intestinal microbiome. Five databases were searched in August 2019 for studies exploring pre-pregnancy or pregnancy ‘exposure’ data in relation to the infant microbiome. Of 1,441 publications identified, 76 were included. Factors reported influencing microbiome composition and diversity included maternal antibiotic and probiotic uses, dietary intake, pre-pregnancy body mass index (BMI), gestational weight gain (GWG), diabetes, mood, and others. Eleven studies contributed to three meta-analyses quantifying associations between maternal intrapartum antibiotic exposure (IAP), BMI and GWG, and infant microbiome alpha diversity (Shannon Index). IAP, maternal overweight/obesity and excessive GWG were all associated with reduced diversity. Most studies were observational, few included early recruitment or longitudinal follow-up, and the timing, frequency, and methodologies related to stool sampling and analysis were variable. Standardization and collaboration are imperative to enhance understanding in this complex and rapidly evolving area.
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DOI：
10.1186/1710-1492-9-15
发表时间：
2013
期刊：
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
影响因子：
--
作者：
Azad MB;Konya T;Maughan H;Guttman DS;Field CJ;Sears MR;Becker AB;Scott JA;Kozyrskyj AL
通讯作者：
Kozyrskyj AL
影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
影响因子：
24.5
作者：
Cani PD
通讯作者：
Cani PD
影响因子：
14.6
作者：
Azad, Meghan B.;Konya, Theodore;Kozyrskyj, Anita L.
通讯作者：
Kozyrskyj, Anita L.
影响因子：
4.4
作者：
Bisanz, Jordan E.;Enos, Megan K.;Reid, Gregor
通讯作者：
Reid, Gregor