A new frontier in temporomandibular joint osteoarthritis treatment: Exosome-based therapeutic strategy.
A new frontier in temporomandibular joint osteoarthritis treatment: Exosome-based therapeutic strategy.
复制标题
颞下颌关节骨关节炎治疗的新前沿：基于外泌体的治疗策略。
DOI：
10.3389/fbioe.2022.1074536
复制
发表时间：
2022
影响因子：
5.7
通讯作者：
Liu, Jin
中科院分区：
文献类型：
--
作者：
Yuan, Wenxiu;Wu, Yange;Huang, Maotuan;Zhou, Xueman;Liu, Jiaqi;Yi, Yating;Wang, Jun;Liu, Jin
关键词：
颞下颌关节骨关节炎（TMJOA）是一种发病率高、影响患者生活质量的退行性疾病。目前，由于病因不明，TMJOA的传统临床策略强调对症治疗，如缓解疼痛和减轻炎症，但无法阻止或逆转软骨或软骨下骨的破坏。大量研究表明，间充质干细胞（MSCs）在TMJOA等软骨损伤治疗中具有潜在的应用前景。值得注意的是，外泌体越来越多地被认为是MSC分泌物用于TMJOA管理的主要有效剂。对来源于骨髓间充质干细胞、滑膜细胞、软骨细胞或脂肪组织等的外泌体的广泛研究，最近，在关节炎上的研究表明，外泌体及其特异性miRNA组分是TMJOA的潜在治疗剂。本文综述了不同来源的MSCs和exosomes在TMJOA中的治疗特性和机制，并对exosomes治疗TMJOA的优化途径、面临的挑战和前景进行了分析和讨论。
Temporomandibular joint osteoarthritis (TMJOA) is a debilitating degenerative disease with high incidence, deteriorating quality of patient life. Currently, due to ambiguous etiology, the traditional clinical strategies of TMJOA emphasize on symptomatic treatments such as pain relief and inflammation alleviation, which are unable to halt or reverse the destruction of cartilage or subchondral bone. A number of studies have suggested the potential application prospect of mesenchymal stem cells (MSCs)-based therapy in TMJOA and other cartilage injury. Worthy of note, exosomes are increasingly being considered the principal efficacious agent of MSC secretions for TMJOA management. The extensive study of exosomes (derived from MSCs, synoviocytes, chondrocytes or adipose tissue et al.) on arthritis recently, has indicated exosomes and their specific miRNA components to be potential therapeutic agents for TMJOA. In this review, we aim to systematically summarize therapeutic properties and underlying mechanisms of MSCs and exosomes from different sources in TMJOA, also analyze and discuss the approaches to optimization, challenges, and prospects of exosome-based therapeutic strategy.
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影响因子：
5.6
作者：
Derwich M;Mitus-Kenig M;Pawlowska E
通讯作者：
Pawlowska E
DOI：
10.1016/j.matbio.2021.07.002
发表时间：
2021-08
期刊：
Matrix biology : journal of the International Society for Matrix Biology
影响因子：
--
作者：
Chandrasekaran P;Kwok B;Han B;Adams SM;Wang C;Chery DR;Mauck RL;Dyment NA;Lu XL;Frank DB;Koyama E;Birk DE;Han L
通讯作者：
Han L
HMGB1通过诱导滑膜血管生成导致颞下颌关节骨关节炎
影响因子：
2.9
作者：
Feng, Yaping;Hu, Shiyu;Long, Xing
通讯作者：
Long, Xing
影响因子：
2.6
作者：
Bartholomew, A;Sturgeon, C;Hoffman, R
通讯作者：
Hoffman, R
影响因子：
4.5
作者：
Bellio, Michael A.;Young, Karen C.;Mitrani, Maria Ines
通讯作者：
Mitrani, Maria Ines