Numerical simulation of a single cell passing through a narrow slit.
Numerical simulation of a single cell passing through a narrow slit.
复制标题
单细胞通过窄缝的数值模拟
DOI：
10.1007/s10237-016-0789-y
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发表时间：
2016-12
影响因子：
3.5
通讯作者：
Fu, B. M.
中科院分区：
文献类型：
--
作者：
Xiao, L. L.;Liu, Y.;Chen, S.;Fu, B. M.
关键词：
The narrow slit between endothelial cells that line the microvessel wall is the principal pathway for tumor cell extravasation to the surrounding tissue. To understand this crucial step for tumor hematogenous metastasis, we used dissipative particle dynamics method to investigate an individual cell passing through a narrow slit numerically. The cell membrane was simulated by a spring-based network model which can separate the internal cytoplasm and surrounding fluid. The effects of the cell elasticity, cell shape, nucleus and slit size on the cell transmigration through the slit were investigated. Under a fixed driving force, the cell with higher elasticity can be elongated more and pass faster through the slit. When the slit width decreases to 2/3 of the cell diameter, the spherical cell becomes jammed despite reducing its elasticity modulus by 10 times. However, transforming the cell from a spherical to ellipsoidal shape and increasing the cell surface area by merely 9.3 % can enable the cell to pass through the narrow slit. Therefore, the cell shape and surface area increase play a more important role than the cell elasticity in cell passing through the narrow slit. In addition, the simulation results indicate that the cell migration velocity decreases during entrance but increases during exit of the slit, which is qualitatively in agreement with the experimental observation.
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DOI：
10.1016/j.cma.2010.02.001
发表时间：
2010-06-01
影响因子：
7.2
作者：
Fedosov DA;Caswell B;Karniadakis GE
通讯作者：
Karniadakis GE
DOI：
10.1016/j.msec.2005.08.020
发表时间：
2006-09-01
期刊：
MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS
影响因子：
--
作者：
Dao, M.;Li, J.;Suresh, S.
通讯作者：
Suresh, S.
DOI：
10.1083/jcb.112.4.719
发表时间：
1991-02
期刊：
The Journal of cell biology
影响因子：
--
作者：
Fushimi K;Verkman AS
通讯作者：
Verkman AS
影响因子：
3.4
作者：
Li, J;Dao, M;Suresh, S
通讯作者：
Suresh, S
影响因子：
3.8
作者：
Fan J;Fu BM
通讯作者：
Fu BM