Ribosomal Protein L10: From Function to Dysfunction.

Ribosomal Protein L10: From Function to Dysfunction.
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DOI:
10.3390/cells9112503
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发表时间:
2020-11-19
期刊:
影响因子:
6
通讯作者:
Penzo M
Penzo M
中科院分区:
生物学2区
文献类型:
--
作者:
Pollutri D;Penzo M

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真核细胞质核糖体是由4种不同的核糖体RNA(rRNA)和80种核糖体蛋白(RP)组成的高度结构化的大分子复合物,其在解码用于合成新蛋白质的遗传密码中起核心作用。在过去的25年中,对酵母和人类模型的研究使得有可能鉴定RPL 10(核糖体蛋白L10基因),其是核糖体大亚基的组成部分,作为核糖体生物发生的最后阶段和核糖体功能的重要参与者。在这里,我们回顾了文献,概述了RPL 10在生理和病理过程中的作用,包括遗传性疾病和癌症。
Eukaryotic cytoplasmic ribosomes are highly structured macromolecular complexes made up of four different ribosomal RNAs (rRNAs) and 80 ribosomal proteins (RPs), which play a central role in the decoding of genetic code for the synthesis of new proteins. Over the past 25 years, studies on yeast and human models have made it possible to identify RPL10 (ribosomal protein L10 gene), which is a constituent of the large subunit of the ribosome, as an important player in the final stages of ribosome biogenesis and in ribosome function. Here, we reviewed the literature to give an overview of the role of RPL10 in physiologic and pathologic processes, including inherited disease and cancer.
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