THETA-Rhythm Makes the World Go Round: Dissociative Effects of TMS Theta Versus Alpha Entrainment of Right pTPJ on Embodied Perspective Transformations.
THETA-Rhythm Makes the World Go Round: Dissociative Effects of TMS Theta Versus Alpha Entrainment of Right pTPJ on Embodied Perspective Transformations.
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DOI：
10.1007/s10548-017-0557-z
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发表时间：
2017-09
期刊：
影响因子：
2.7
通讯作者：
Kessler K
中科院分区：
文献类型：
--
作者：
Gooding-Williams G;Wang H;Kessler K
能够想象另一个人的经历和对世界的看法是一项至关重要的人类能力，最近的报告表明，人类通过在精神上将自己的身体表征旋转成另一个人的方向来“体现”另一个人的观点。我们最近的脑磁图（MEG）数据进一步证实了具体化视角转换的概念，并指出右侧后颞顶叶连接（pTPJ）是在θ频率（3-7 Hz）振荡的分布式网络中的关键枢纽。在随后的经颅磁刺激（TMS）实验中，我们干扰了右侧pTPJ加工，并观察到视角转换的体现方面的调制。虽然这些结果证实了右pTPJ的作用，但基于我们的MEG数据，θ振荡是关键神经编码的概念仍然是一个相关的观察。因此，在目前的研究中，我们着手通过TMS夹带直接确认θ振荡的重要性。我们比较了右侧pTPJ在6 Hz和10 Hz时的夹带，证实只有6 Hz的夹带促进了具身视角转换（在160°角视差下），而10 Hz的夹带减慢了它。相反，在低角度视差（自我中心和目标视角之间的60°）下，透视转换不是严格必要的。我们的研究结果进一步证实了pTPJ参与了具身视角转换，并强调了theta振荡是一个重要的神经编码。本文的在线版本（doi:10.1007/s10548-017-0557-z）包含补充材料，仅供授权用户使用。
Being able to imagine another person’s experience and perspective of the world is a crucial human ability and recent reports suggest that humans “embody” another’s viewpoint by mentally rotating their own body representation into the other’s orientation. Our recent Magnetoencephalography (MEG) data further confirmed this notion of embodied perspective transformations and pinpointed the right posterior temporo-parietal junction (pTPJ) as the crucial hub in a distributed network oscillating at theta frequency (3–7 Hz). In a subsequent transcranial magnetic stimulation (TMS) experiment we interfered with right pTPJ processing and observed a modulation of the embodied aspects of perspective transformations. While these results corroborated the role of right pTPJ, the notion of theta oscillations being the crucial neural code remained a correlational observation based on our MEG data. In the current study we therefore set out to confirm the importance of theta oscillations directly by means of TMS entrainment. We compared entrainment of right pTPJ at 6 Hz vs. 10 Hz and confirmed that only 6 Hz entrainment facilitated embodied perspective transformations (at 160° angular disparity) while 10 Hz slowed it down. The reverse was true at low angular disparity (60° between egocentric and target perspective) where a perspective transformation was not strictly necessary. Our results further corroborate right pTPJ involvement in embodied perspective transformations and highlight theta oscillations as a crucial neural code. The online version of this article (doi:10.1007/s10548-017-0557-z) contains supplementary material, which is available to authorized users.
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