Potential biological functions of microvesicles derived from adenoid cystic carcinoma.
Potential biological functions of microvesicles derived from adenoid cystic carcinoma.
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腺样囊性癌微泡的潜在生物学功能
DOI：
10.3892/ol.2018.8296
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发表时间：
2018-05
期刊：
影响因子：
2.9
通讯作者：
Li L
中科院分区：
文献类型：
--
作者：
Zhang Z;Yan C;Li B;Li L
Microvesicles (MVs) are secreted by multiple types of tumor cell and are involved in tumor progression and metastasis. The aim of the present study was to explore the effects of MVs derived from salivary adenoid cystic carcinoma (SACC) and to investigate their potential involvement in the pathogenesis of perineural invasion of SACC. MVs were isolated from ACCs cells, and differential gene expression profiles of these MVs were compared with their donor cells to speculate on their biological functions. Several candidate genes were validated using reverse transcription-quantitative polymerase chain reaction analysis. The effects of ACCs MVs on rat Schwann cells (RSC96 cells), which are the principal glia of the peripheral nervous system, were then evaluated by phospho-antibody array performed on RSC96 cells transduced with ACCs MVs. The results indicated that ACCs cells may produce MVs. Microarray-based expression profiles between ACCs cells and their MVs identified 1,355 genes involved in cell adhesion, development and the regulation of apoptosis. In addition, the extracellular signal-regulated protein kinase signal pathway in RSC96 cells may be induced by ACCs-derived MVs. These results may help to elucidate the mechanisms underlying perineural invasion in SACC, and to determine a promising anti-tumor biological therapeutic target.
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DOI：
10.1038/nrm2937
发表时间：
2010-08
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
通讯作者：
--
影响因子：
3.7
作者：
Phuchareon J;Ohta Y;Woo JM;Eisele DW;Tetsu O
通讯作者：
Tetsu O
影响因子：
21.3
作者：
Skog, Johan;Wuerdinger, Tom;van Rijn, Sjoerd;Meijer, Dimphna H.;Gainche, Laura;Sena-Esteves, Miguel;Curry, William T., Jr.;Carter, Bob S.;Krichevsky, Anna M.;Breakefield, Xandra O.
通讯作者：
Breakefield, Xandra O.
叉头转录因子FOXO1/3/4通过受体酪氨酸激酶PDGFRA调节神经母细胞瘤分化
DOI：
10.1073/pnas.1119535109
发表时间：
2012-03-27
影响因子：
11.1
作者：
Mei, Yang;Wang, Zhanxiang;You, Han
通讯作者：
You, Han
影响因子：
11.4
作者：
Bianco, Fabio;Perrotta, Cristiana;Novellino, Luisa;Francolini, Maura;Riganti, Loredana;Menna, Elisabetta;Saglietti, Laura;Schuchman, Edward H.;Furlan, Roberto;Clementi, Emilio;Matteoli, Michela;Verderio, Claudia
通讯作者：
Verderio, Claudia