Early declines in physical function among aging adults with type 2 diabetes.
Early declines in physical function among aging adults with type 2 diabetes.
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DOI：
10.1016/j.jdiacomp.2016.06.022
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发表时间：
2017-02
影响因子：
3
通讯作者：
Quinn L
中科院分区：
文献类型：
--
作者：
Fritschi C;Bronas UG;Park CG;Collins EG;Quinn L
2型糖尿病（T2 DM）与身体功能下降和早期残疾有关。我们假设身体功能的变化发生在早期，并因年龄而异。我们的目的是确定和比较老年和年轻T2 DM患者身体功能的差异和预测因素。80名成年人完成了6分钟步行距离（6 MWD）测试，佩戴腕关节活动仪5天，并完成了糖尿病健康和症状调查。完成比较和双变量分析，以评估通过连续Box's M-图分析确定的年龄组之间的差异。6 MWD较低（476.9 ± 106.2 m），与女性性别、年龄、神经性疼痛、糖尿病病程、BMI、睡眠质量差、疲劳呈负相关，与习惯性活动和教育呈正相关（p < 0.05）。协方差矩阵在59岁时发生变化。在年龄< 58岁的受试者中，性别、睡眠质量和神经性疼痛可预测6 MWD（R2 0.593，p < 0.001）。在年龄≥ 59岁的患者中，糖尿病病程、受教育程度和习惯性活动可预测6 MWD（R2 0.554，p < 0.001）。两组之间没有共同的6 MWD预测因子。T2 DM与身体功能的早期下降有关;其预测因素在中年发生变化。维持或改善身体功能的治疗应根据年龄，疼痛症状和习惯性活动水平进行调整。
Type 2 (T2DM) diabetes is associated with reduced physical function and early disability. We hypothesized that changes in physical function occur early and differ by age. Our aims were to determine and compare differences in and predictors of physical function in older and younger adults with T2DM. Eighty adults completed six-minute walk distance (6MWD) tests, wore wrist actigraphy for 5 days and completed diabetes health and symptom surveys. Comparative and bivariate analyses were completed to assess differences between age groups determined by serial Box’s M-plot analyses. 6MWD was low (476.9 ± 106.2 m), and negatively associated with female gender, age, neuropathic pain, diabetes duration, BMI, poor sleep quality, and fatigue and positively with habitual activity and education (p < 0.05). Covariance matrices changed at age 59. In subjects age < 58, 6MWD was predicted by gender, sleep quality, and neuropathic pain (R2 0.593, p < 0.001). In those age ≥ 59, 6MWD was predicted by diabetes duration, education, and habitual activity (R2 0.554, p < 0.001). There were no shared predictors of 6MWD between groups. T2DM is associated with early declines in physical function; the predictors of which change in mid-life. Therapies to maintain or improve physical function should be tailored by age, pain symptoms, and habitual activity levels.
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影响因子：
7.7
作者：
Park, Seok Won;Goodpaster, Bret H.;Newman, Anne B.
通讯作者：
Newman, Anne B.
影响因子：
1.3
作者：
Alfonso-Rosa, Rosa M.;del Pozo-Cruz, Borja;Rogers, Michael E.
通讯作者：
Rogers, Michael E.
影响因子：
2.5
作者：
Fritschi C;Park H;Richardson A;Park C;Collins EG;Mermelstein R;Riesche L;Quinn L
通讯作者：
Quinn L
影响因子：
4.8
作者：
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通讯作者：
Marchesini G
影响因子：
16.2
作者：
Gregg, EW;Breckles, GLA;Narayan, KMV
通讯作者：
Narayan, KMV