Inhibitory spillover: intentional motor inhibition produces incidental limbic inhibition via right inferior frontal cortex.
Inhibitory spillover: intentional motor inhibition produces incidental limbic inhibition via right inferior frontal cortex.
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DOI：
10.1016/j.neuroimage.2009.04.084
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发表时间：
2009-08-15
期刊：
影响因子：
5.7
通讯作者：
Lieberman, Matthew D.
中科院分区：
文献类型：
--
作者：
Berkman, Elliot T.;Burklund, Lisa;Lieberman, Matthew D.
神经认知研究已经观察到rIFC参与运动、认知和情感抑制，表明rIFC是跨心理领域的常见抑制机制。如果为真，则在一个域中的有意抑制可能在其他域中产生非有意的抑制效应（“溢出”）。本研究采用情绪去/不去任务，产生的反应，在运动和情感领域，但诱导故意抑制，只有运动领域。数据支持这一假设，故意抑制在运动领域，通过rIFC，产生抑制溢出的情感领域。具体来说，我们观察到增加rIFC沿着杏仁核活动减少，当参与者在呈现负价刺激期间故意抑制运动反应时，以及在PPI分析中运动抑制期间这些区域之间更大的反向连接。考虑到没有故意的影响调节，这些结果表明，故意抑制运动反应抑制杏仁核激活符合情感刺激的程度，rIFC激活较高。
Neurocognitive studies have observed rIFC involvement in motor, cognitive, and affective inhibition, suggesting that rIFC is a common inhibitory mechanism across psychological domains. If true, intentional inhibition in one domain may have unintended inhibitory effects (‘spillover’) in other domains. The present study used an emotional go/no-go task that produces responses in both motor and affective domains, but induces intentional inhibition in only the motor domain. Data support the hypothesis that intentional inhibition in the motor domain, via rIFC, produces inhibitory spillover in the affective domain. Specifically, we observed increased rIFC along with reduced amygdala activity when participants intentionally inhibited motor responses during the presentation of negatively-valenced stimuli, and greater inverse connectivity between these regions during motor inhibition in a PPI analysis. Given the absence of intentional affect regulation, these results suggest that intentional inhibition of a motor response dampens the amygdala activation coincident with affective stimuli to the extent that rIFC activation is higher.
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