Genomics of bacteria and archaea: the emerging dynamic view of the prokaryotic world.
Genomics of bacteria and archaea: the emerging dynamic view of the prokaryotic world.
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细菌和古细菌的基因组学：原核生物世界的新兴动态视野。
DOI：
10.1093/nar/gkn668
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发表时间：
2008-12
影响因子：
14.9
通讯作者：
Wolf, Yuri I.
中科院分区：
文献类型：
--
作者：
Koonin, Eugene V.;Wolf, Yuri I.
第一个细菌基因组在1995年被测序，第一个古细菌基因组在1996年被测序。在这些突破之后不久，建立了基因组测序的指数速率，细菌的倍增时间约为20个月，古细菌约为34个月。对数百个测序的细菌和数十个古细菌基因组的比较分析导致了对基因组组织和进化原理的几个概括。一个关键的发现，使测序基因组的功能表征和进化重建是，大多数古细菌和细菌基因在其他，往往是遥远的生物体保守的直系同源物。然而，比较基因组学也表明，水平基因转移（HGT）是原核生物进化的主导力量，沿着遗传物质的丢失导致基因组收缩。原核世界的一个重要组成部分是活动组，它是病毒、质粒和其他自私元素的巨大集合，它们与更稳定的染色体不断交换，并充当HGT载体。因此，原核生物基因组空间是一个紧密相连的，虽然划分，网络，一个新的概念，破坏了“生命之树”的进化模型，并需要一个新的概念框架和工具的研究原核生物进化。
The first bacterial genome was sequenced in 1995, and the first archaeal genome in 1996. Soon after these breakthroughs, an exponential rate of genome sequencing was established, with a doubling time of approximately 20 months for bacteria and approximately 34 months for archaea. Comparative analysis of the hundreds of sequenced bacterial and dozens of archaeal genomes leads to several generalizations on the principles of genome organization and evolution. A crucial finding that enables functional characterization of the sequenced genomes and evolutionary reconstruction is that the majority of archaeal and bacterial genes have conserved orthologs in other, often, distant organisms. However, comparative genomics also shows that horizontal gene transfer (HGT) is a dominant force of prokaryotic evolution, along with the loss of genetic material resulting in genome contraction. A crucial component of the prokaryotic world is the mobilome, the enormous collection of viruses, plasmids and other selfish elements, which are in constant exchange with more stable chromosomes and serve as HGT vehicles. Thus, the prokaryotic genome space is a tightly connected, although compartmentalized, network, a novel notion that undermines the ‘Tree of Life’ model of evolution and requires a new conceptual framework and tools for the study of prokaryotic evolution.
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影响因子：
3.4
作者：
Bapteste E;Susko E;Leigh J;MacLeod D;Charlebois RL;Doolittle WF
通讯作者：
Doolittle WF
影响因子：
2.4
作者：
Bapteste, Eric;Brochier, Celine;Boucher, Yan
通讯作者：
Boucher, Yan
DOI：
10.1073/pnas.0504068102
发表时间：
2005-10-04
影响因子：
11.1
作者：
Beiko, RG;Harlow, TJ;Ragan, MA
通讯作者：
Ragan, MA
影响因子：
14.9
作者：
Babu, MM;Teichmann, SA
通讯作者：
Teichmann, SA
影响因子：
64.8
作者：
Cole, ST;Eiglmeier, K;Barrell, BG
通讯作者：
Barrell, BG