Plasma Proteins As Biodosimetric Markers of Low-Dose Radiation in Mice.
Plasma Proteins As Biodosimetric Markers of Low-Dose Radiation in Mice.
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血浆蛋白作为小鼠低剂量辐射的生物剂量标记物
DOI：
10.1177/15593258211016257
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Fu H
中科院分区：
文献类型：
--
作者：
Ge C;Liang Y;Zhang Y;Su F;Chen L;Ma F;Ding K;Zhu J;Zheng X;Fu H
Long-term exposures to low-dose radiation (LDR) may trigger several specific biological responses, including dysregulation of the immune and inflammatory systems. Here, we examined whether biodosimetry of LDR can be used to protect tissues from radiation or assess cancer risk. Mice were subjected to gamma-irradiation with repeated or single-dose LDR, and then the organ indices, peripheral hemogram, and blood biochemistry were analyzed. An antibody array was applied followed by enzyme-linked immunosorbent assay to evaluate the utility of multiple plasma proteins as biomarkers of repeated LDR in a murine model. LDR induced inapparent symptoms but slight variations in peripheral blood cell counts and alterations in blood biochemical indicator levels. Specific plasma proteins in the LDR groups were altered in response to a higher dose of irradiation at the same time points or a single-dose equivalent to the same total dose. Plasma levels of interleukin (IL)-5, IL-12p40, P-selectin, and serum amyloid A1 were associated with the LDR dose and thus may be useful as dosimetric predictors of LDR in mice. Estimating the levels of certain plasma proteins may yield promising biodosimetry parameters to accurately identify individuals exposed to LDR, facilitating risk assessment of long-term LDR exposure in individuals.
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DOI：
10.1177/1559325818799561
发表时间：
2018-07
期刊：
Dose-response : a publication of International Hormesis Society
影响因子：
--
作者：
Liang X;Zheng S;Cui J;Yu D;Yang G;Zhou L;Wang B;Cai L;Li W
通讯作者：
Li W
暴露于长期低剂量电离辐射的铀矿工中细胞因子谱的改变。
影响因子：
--
作者：
Li K;Chen Y;Li X;Lei S;Chen Q;Liu J;Sun Q
通讯作者：
Sun Q
影响因子：
3.4
作者：
Kim, Sup;Choe, Jin Ho;Kim, Jun-Sang
通讯作者：
Kim, Jun-Sang
影响因子：
--
作者：
Huang, Jinfeng;Qi, Zhenhua;Wang, Zhidong
通讯作者：
Wang, Zhidong
影响因子：
21.1
作者：
Jiang DW;Wang QR;Shen XR;He Y;Qian TT;Liu Q;Hou DY;Liu YM;Chen W;Ren X;Li KX
通讯作者：
Li KX