Natural agents: cellular and molecular mechanisms of photoprotection.
Natural agents: cellular and molecular mechanisms of photoprotection.
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DOI：
10.1016/j.abb.2010.12.007
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发表时间：
2011-04-15
影响因子：
3.9
通讯作者：
Afaq F
中科院分区：
文献类型：
--
作者：
Afaq F
皮肤是人体最大的器官，它能产生灵活的自我修复屏障，保护身体免受最常见的潜在有害的物理、环境和生物伤害。太阳紫外线（UV）辐射是对皮肤的主要环境伤害之一，并引起多层细胞和分子事件，最终导致皮肤癌。在过去的十年中，由于生活方式的改变导致人们接受的紫外线辐射显著增加，皮肤癌的发病率激增。减少过度暴露于紫外线辐射是可取的；然而，这种方法并不容易实现。因此，迫切需要开发新的策略来减少紫外线辐射对皮肤的不良生物效应。据报道，各种各样的天然制剂具有实质性的皮肤光保护作用。许多临床前和临床研究已经阐明了天然药物通过几种细胞和分子机制来延缓或预防皮肤癌。在这篇综述文章中，我们总结和讨论了一些选择的天然皮肤光防护剂。
The skin is the largest organ of the body that produces a flexible and self-repairing barrier and protects the body from most common potentially harmful physical, environmental, and biological insults. Solar ultraviolet (UV) radiation is one of the major environmental insults to the skin and causes multi-tiered cellular and molecular events eventually leading to skin cancer. The past decade has seen a surge in the incidence of skin cancer due to changes in life style patterns that have led to a significant increase in the amount of UV radiation that people receive. Reducing excessive exposure to UV radiation is desirable; nevertheless this approach is not easy to implement. Therefore, there is an urgent need to develop novel strategies to reduce the adverse biological effects of UV radiation on the skin. A wide variety of natural agents have been reported to possess substantial skin photoprotective effects. Numerous preclinical and clinical studies have elucidated that natural agents act by several cellular and molecular mechanisms to delay or prevent skin cancer. In this review article, we have summarized and discussed some of the selected natural agents for skin photoprotection.
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影响因子：
3.6
作者：
Afaq F;Zaid MA;Khan N;Dreher M;Mukhtar H
通讯作者：
Mukhtar H
影响因子：
8
作者：
Afaq, F;Ahmad, N;Mukhtar, H
通讯作者：
Mukhtar, H
影响因子：
11.2
作者：
Byun, Sanguine;Lee, Ki Won;Dong, Zigang
通讯作者：
Dong, Zigang
影响因子：
3.8
作者：
Afaq, F;Adhami, VM;Ahmad, N
通讯作者：
Ahmad, N
影响因子：
8
作者：
Afaq, F;Adhami, VM;Mukhtar, H
通讯作者：
Mukhtar, H