Brainstem Neuronal Circuitries Controlling Gastric Tonic and Phasic Contractions: A Review.
Brainstem Neuronal Circuitries Controlling Gastric Tonic and Phasic Contractions: A Review.
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DOI：
10.1007/s10571-021-01084-5
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发表时间：
2022-03
影响因子：
4
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中科院分区：
文献类型：
--
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本文就近40年来本课题组对脑干对胃机械功能控制的研究进展作一综述。它描述了大量不同类型研究的数据，包括逆行神经元追踪、药物显微注射、啮齿动物脑切片的全细胞记录、接受性松弛反射、调节反射、c-Fos实验、免疫组织化学方法、电子显微镜、转基因小鼠、光遗传学和GABA能信号。结果表明：（1）孤束核（NTS）-迷走神经背侧运动核（DMV）的去甲肾上腺素能联系是胃底反射控制所必需的，（2）NTS的二级氮能神经元也是胃底反射控制所必需的，（3）NTS的GABA能联系是胃窦反射控制所必需的，（4）NTS的GABA能神经元也是胃窦反射控制所必需的。（4）除调节反射外，大多数实验条件下，DMV传出通路参与脑干对胃机械功能的控制。双迷走神经效应器控制胆碱能和非肾上腺素能和非胆碱能（NANC）输入到胃可能是这种反射的电路的一部分。(5)NTS内通过Sst-GABA中间神经元的GABA能信号传导决定胃张力和阶段性收缩的基础（静息）状态。(6)为了使迷走神经-迷走神经反射变得可操作，NTS中的内源性阿片样物质被释放，并且Sst-GABA中间神经元的活性被抑制。从这些数据中，我们认为，中枢神经系统有能力提供区域特异性控制近端（胃底）和远端（胃窦）的胃，通过从事表型不同的传出输入DMV。
This review is on how current knowledge of brainstem control of gastric mechanical function unfolded over nearly four decades from the perspective of our research group. It describes data from a multitude of different types of studies involving retrograde neuronal tracing, microinjection of drugs, whole-cell recordings from rodent brain slices, receptive relaxation reflex, accommodation reflex, c-Fos experiments, immunohistochemical methods, electron microscopy, transgenic mice, optogenetics, and GABAergic signaling. Data obtained indicate the following: (1) nucleus tractus solitarius (NTS)—dorsal motor nucleus of the vagus (DMV) noradrenergic connection is required for reflex control of the fundus; (2) second-order nitrergic neurons in the NTS are also required for reflex control of the fundus; (3) a NTS GABAergic connection is required for reflex control of the antrum; (4) a single DMV efferent pathway is involved in brainstem control of gastric mechanical function under most experimental conditions excluding the accommodation reflex. Dual-vagal effectors controlling cholinergic and non-adrenergic and non-cholinergic (NANC) input to the stomach may be part of the circuitry of this reflex. (5) GABAergic signaling within the NTS via Sst-GABA interneurons determine the basal (resting) state of gastric tone and phasic contractions. (6) For the vagal–vagal reflex to become operational, an endogenous opioid in the NTS is released and the activity of Sst-GABA interneurons is suppressed. From the data, we suggest that the CNS has the capacity to provide region-specific control over the proximal (fundus) and distal (antrum) stomach through engaging phenotypically different efferent inputs to the DMV.
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DOI：
10.1111/j.1748-1716.1969.tb04561.x
发表时间：
1969-01-01
期刊：
ACTA PHYSIOLOGICA SCANDINAVICA
影响因子：
--
作者：
ABRAHAMSSON, H;JANSSON, G
通讯作者：
JANSSON, G
DOI：
10.1046/j.1440-1681.2000.03291.x
发表时间：
2000-07-01
影响因子：
2.9
作者：
Christie, MJ;Connor, M;Bagley, EE
通讯作者：
Bagley, EE
影响因子：
2.5
作者：
Fanselow, Erika E.;Connors, Barry W.
通讯作者：
Connors, Barry W.
DOI：
10.1152/ajpregu.00003.2005
发表时间：
2005-11-01
影响因子：
2.8
作者：
Ferreira, M;Sahibzada, N;Gillis, RA
通讯作者：
Gillis, RA
影响因子：
5.3
作者：
Ferreira, M;Sahibzada, N;Gillis, RA
通讯作者：
Gillis, RA