Helicobacter pylori and Gastric Mucus Integrity

Helicobacter pylori and Gastric Mucus Integrity
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幽门螺杆菌和胃粘液完整性

DOI:
10.1007/978-3-642-75726-6_8
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发表时间:
1991
期刊:
Molecular and chemical neuropathology
影响因子:
--
通讯作者:
A. Slomiany
A. Slomiany
中科院分区:
--
文献类型:
--
作者:
B. Slomiany;V. Murty;J. Piotrowski;S.;A. Slomiany

文献摘要

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胃粘膜的一个独特性质是其能够承受腔内容物施加的损伤并抵抗入侵细菌的挑战。尽管对粘膜保护机制尚未达成普遍共识,但共识是这种现象本质上是多组分的,至少包括三个主要防御周界,即粘液-碳酸氢盐区、胃上皮细胞膜和粘膜血流[1-4]。因此,至少在初始阶段,腔损伤的冲击福尔斯在粘液层上,粘液层构成胃腔和粘膜表面上皮细胞之间唯一可识别的物理屏障。这种防御周界的完整性取决于微妙的动态平衡,由影响其成分的合成,分泌和分解的因素控制[3,5,6]。虽然在正常生理条件下成功地维持了这种平衡,但当攻击性力量克服了控制粘膜防御的因素时,粘膜损伤就会加剧。
A unique property of gastric mucosa is its ability to withstand the insults imposed by the luminal contents and to resist the challenge by invading bacteria. Although there is no general agreement as to the mechanism of mucosal protection, the consensus is that this phenomenon is multicomponential in nature, and includes at least three major defense perimeters, which are the mucus-bicarbonate zone, the cell membranes of gastric epithelium, and the mucosal blood flow [1–4]. Hence, the brunt of luminal insults, at least in the initial stage, falls on the mucus layer, which constitutes the only identifiable physical barrier between the gastric lumen and the surface epithelial cells of the mucosa. The integrity of this defense perimeter depends upon a delicate dynamic equilibrium, controlled by factors affecting the synthesis, secretion, and breakdown of its constituents [3, 5, 6]. While this equilibrium is maintained successfully under normal physiological conditions, injury to the mucosa ensues when aggressive forces overcome factors that control mucosal defense.
DOI: 10.1111/j.1572-0241.1989.tb02571.x
发表时间: 1989-05
期刊: The American journal of gastroenterology
影响因子: --
作者:
J. Sarosiek;J. Bilski;V. Murty;A. Slomiany;B. Slomiany
通讯作者: J. Sarosiek;J. Bilski;V. Murty;A. Slomiany;B. Slomiany
在乙醇存在下培养的粘膜细胞合成和分泌胃粘液糖蛋白。
DOI: 10.1016/0003-9861(85)90670-8
发表时间: 1985
影响因子: 3.9
作者:
Slomiany,A;Takagi,A;Slomiany,BL
通讯作者: Slomiany,BL
DOI: 10.1159/000171168
发表时间: 1987
期刊: Digestive diseases
影响因子: 2.3
作者:
B. Slomiany;J. Sarosiek;A. Slomiany
通讯作者: B. Slomiany;J. Sarosiek;A. Slomiany
共价结合脂肪酸和相关脂质对囊性纤维化中胃粘液糖蛋白粘度的影响。
DOI: 10.1159/000199341
发表时间: 1986
期刊: Digestion
影响因子: 3.2
作者:
Slomiany,BL;Murty,VL;Carter,SR;Slomiany,A
通讯作者: Slomiany,A
共价结合脂肪酸在人胃粘液糖蛋白降解中的作用。
DOI: 10.1016/0003-9861(84)90188-7
发表时间: 1984
影响因子: 3.9
作者:
Slomiany,A;Jozwiak,Z;Takagi,A;Slomiany,BL
通讯作者: Slomiany,BL