Helicobacter pylori and Gastric Mucus Integrity
Helicobacter pylori and Gastric Mucus Integrity
复制标题
幽门螺杆菌和胃粘液完整性
DOI:
10.1007/978-3-642-75726-6_8
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发表时间:
1991
期刊:
影响因子:
--
通讯作者:
A. Slomiany
中科院分区:
文献类型:
--
作者:
B. Slomiany;V. Murty;J. Piotrowski;S.;A. Slomiany
A unique property of gastric mucosa is its ability to withstand the insults imposed by the luminal contents and to resist the challenge by invading bacteria. Although there is no general agreement as to the mechanism of mucosal protection, the consensus is that this phenomenon is multicomponential in nature, and includes at least three major defense perimeters, which are the mucus-bicarbonate zone, the cell membranes of gastric epithelium, and the mucosal blood flow [1–4]. Hence, the brunt of luminal insults, at least in the initial stage, falls on the mucus layer, which constitutes the only identifiable physical barrier between the gastric lumen and the surface epithelial cells of the mucosa. The integrity of this defense perimeter depends upon a delicate dynamic equilibrium, controlled by factors affecting the synthesis, secretion, and breakdown of its constituents [3, 5, 6]. While this equilibrium is maintained successfully under normal physiological conditions, injury to the mucosa ensues when aggressive forces overcome factors that control mucosal defense.
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DOI:
10.1111/j.1572-0241.1989.tb02571.x
发表时间:
1989-05
期刊:
The American journal of gastroenterology
影响因子:
--
作者:
J. Sarosiek;J. Bilski;V. Murty;A. Slomiany;B. Slomiany
通讯作者:
J. Sarosiek;J. Bilski;V. Murty;A. Slomiany;B. Slomiany
影响因子:
3.9
作者:
Slomiany,A;Takagi,A;Slomiany,BL
通讯作者:
Slomiany,BL
影响因子:
2.3
作者:
B. Slomiany;J. Sarosiek;A. Slomiany
通讯作者:
B. Slomiany;J. Sarosiek;A. Slomiany
影响因子:
3.2
作者:
Slomiany,BL;Murty,VL;Carter,SR;Slomiany,A
通讯作者:
Slomiany,A
影响因子:
3.9
作者:
Slomiany,A;Jozwiak,Z;Takagi,A;Slomiany,BL
通讯作者:
Slomiany,BL