A high docosahexaenoic acid diet alters lung inflammation and recovery following repetitive exposure to aqueous organic dust extracts.
A high docosahexaenoic acid diet alters lung inflammation and recovery following repetitive exposure to aqueous organic dust extracts.
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DOI：
10.1016/j.jnutbio.2021.108797
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发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Nordgren TM
中科院分区：
文献类型：
--
作者：
Ulu A;Burr A;Heires AJ;Pavlik J;Larsen T;Perez PA;Bravo C;DiPatrizio NV;Baack M;Romberger DJ;Nordgren TM
Agricultural workers, especially those who work in swine confinement facilities, are at increased risk for developing pulmonary diseases including asthma, chronic obstructive pulmonary disease, and chronic bronchitis due to exposures to fumes, vapors, and organic dust. Repetitive exposure to agricultural dust leads to unresolved inflammation, a common underlying mechanism that worsens lung disease. Besides occupational exposure to dusts, diet also significantly contributes to inflammation and disease progression. Since DHA (docosahexaenoic acid), a polyunsaturated omega-3 fatty acid and its bioactive metabolites have key roles in inflammation resolution, we rationalized that individuals chronically exposed to organic dusts can benefit from dietary modifications. Here, we evaluated the role of DHA in modifying airway inflammation in a murine model of repetitive exposure to an aqueous extract of agricultural dust (three-week exposure to swine confinement dust extract, HDE) and after a one-week resolution/recovery period. We found that mice fed a high DHA diet had significantly increased bronchoalveolar lavage fluid (BALF) levels of DHA-derived resolvins and lower TNFα along with altered plasma levels of endocannabinoids and related lipid mediators. Following the one-week recovery we identified significantly reduced BALF cellularity and cytokine/chemokine release along with increased BALF amphiregulin and resolvins in DHA diet-fed versus control diet-fed mice challenged with HDE. We further report observations on the effects of repetitive HDE exposure on lung Ym1+ and Arg-1+ macrophages. Overall, our findings support a protective role for DHA and identify DHA-derived resolvins and endocannabinoids among the potential mediators of DHA in altering airway inflammation in chronic agricultural dust exposure.
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影响因子：
4.6
作者：
Di Paola M;Bonechi E;Provensi G;Costa A;Clarke G;Ballerini C;De Filippo C;Passani MB
通讯作者：
Passani MB
DOI：
10.1073/pnas.101119098
发表时间：
2001-05-22
影响因子：
11.1
作者：
Berger, A;Crozier, G;Di Marzo, V
通讯作者：
Di Marzo, V
影响因子：
8
作者：
通讯作者：
--
影响因子：
7.3
作者：
Bates MA;Akbari P;Gilley KN;Wagner JG;Li N;Kopec AK;Wierenga KA;Jackson-Humbles D;Brandenberger C;Holian A;Benninghoff AD;Harkema JR;Pestka JJ
通讯作者：
Pestka JJ
影响因子：
--
作者：
Cotogni P;Trombetta A;Muzio G;Maggiora M;Canuto RA
通讯作者：
Canuto RA