Socio-demographic and clinical predictors of outcome to long-term treatment with lithium in bipolar disorders: a systematic review of the contemporary literature and recommendations from the ISBD/IGSLI Task Force on treatment with lithium.
Socio-demographic and clinical predictors of outcome to long-term treatment with lithium in bipolar disorders: a systematic review of the contemporary literature and recommendations from the ISBD/IGSLI Task Force on treatment with lithium.
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两极疾病中锂长期治疗结果的社会人口统计学和临床预测因素：对当代文献的系统评价和ISBD/IGSLI锂治疗的建议。
DOI：
10.1186/s40345-020-00203-3
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发表时间：
2020-12-16
影响因子：
4
通讯作者：
ISBD-IGSLI Joint Task Force on Lithium Treatment
中科院分区：
文献类型：
--
作者：
Grillault Laroche D;Etain B;Severus E;Scott J;Bellivier F;ISBD-IGSLI Joint Task Force on Lithium Treatment
在接受锂盐长期治疗的诊断为双相情感障碍（BD）的成人患者中，确定与良好结局（GO）和不良结局（PO）相关的可能社会人口统计学和临床因素。对主要电子数据库进行了全面检索，以确定相关研究，包括诊断为BD的成人患者（18岁或以上），并报告了与锂长期治疗（> = 6个月）期间的治疗反应和/或疾病结局相关的社会人口统计学和/或临床变量。研究的质量使用国家卫生研究所的观察性队列和横断面研究质量评估工具进行评分。审查后，34篇出版物（来自31个独立数据集）符合纳入本综述的条件。其中大多数（n = 25）采用回顾性设计。只有11项研究被评为良好或边缘良好质量。确定了43个潜在的锂结局预测因子。四个因素与口服锂相关：酒精使用障碍;人格障碍;较高的住院次数和快速循环模式。两个因素与锂盐治疗患者的GO相关：良好的社会支持和BD的发作性进展。然而，当研究结果的综合仅限于最高（良好或临界良好）质量的研究（11项研究）时，只有更高的终生住院次数与PO至锂相关，而GO至锂无相关性。尽管对锂及其临床应用进行了数十年的研究，但除了终生住院次数外，尚未发现与锂的GO或PO一致相关的因素。因此，在我们对锂治疗结果的预测因素的理解方面仍然存在很大的差距，这表明需要对大型代表性样本进行高质量的研究。
To identify possible socio-demographic and clinical factors associated with Good Outcome (GO) as compared with Poor Outcome (PO) in adult patients diagnosed with Bipolar Disorder (BD) who received long-term treatment with lithium. A comprehensive search of major electronic databases was performed to identify relevant studies that included adults patients (18 years or older) with a diagnosis of BD and reported sociodemographic and/or clinical variables associated with treatment response and/or with illness outcome during long-term treatment to lithium (> = 6 months). The quality of the studies was scored using the Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies from the National Institute of Health. Following review, 34 publications (from 31 independent datasets) were eligible for inclusion in this review. Most of them (n = 25) used a retrospective design. Only 11 studies were graded as good or borderline good quality. Forty-three potential predictors of outcome to lithium were identified. Four factors were associated with PO to lithium: alcohol use disorder; personality disorders; higher lifetime number of hospital admissions and rapid cycling pattern. Two factors were associated with GO in patients treated with lithium: good social support and episodic evolution of BD. However, when the synthesis of findings was limited to the highest (good or borderline good) quality studies (11 studies), only higher lifetime number of hospitalization admissions remained associated with PO to lithium and no associations remained for GO to lithium. Despite decades of research on lithium and its clinical use, besides lifetime number of hospital admissions, no factor being consistently associated with GO or PO to lithium was identified. Hence, there remains a substantial gap in our understanding of predictors of outcome of lithium treatment indicating there is a need of high quality research on large representative samples.
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影响因子：
3.3
作者：
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通讯作者：
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影响因子：
6.6
作者：
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影响因子：
5.4
作者：
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通讯作者：
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影响因子：
3.2
作者：
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通讯作者：
Engelsmann, F
影响因子：
6.7
作者：
Etain, B.;Lajnef, M.;Bellivier, F.
通讯作者：
Bellivier, F.