Repressors of anthocyanin biosynthesis.
Repressors of anthocyanin biosynthesis.
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DOI：
10.1111/nph.17397
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发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Yuan YW
中科院分区：
文献类型：
--
作者：
LaFountain AM;Yuan YW
花色素苷在植物的营养组织和生殖器官中发挥着多种适应性作用。这些化合物的广泛功能需要对花青素苷生物合成途径进行复杂的调节，以允许色素沉积的适当定位、定时和最佳强度。虽然它是公认的，花色素苷生物合成的承诺步骤被激活的高度保守的MYB-bHLH-WDR（MBW）蛋白复合物在几乎所有的开花植物，花色素苷的抑制似乎是由各种各样的蛋白质和小RNA家族，在不同的组织类型和响应不同的发育，环境和激素的线索功能。本文综述了近年来花色素苷阻遏物的鉴定及其分子机制的研究进展。我们发现，这些看似非常不同的压抑模块通过一个非常相似的逻辑，所谓的“双重否定逻辑”。花色素苷产生的双重负调控大多涉及信号诱导的MBW蛋白复合物中阻遏物的降解或螯合。我们讨论的功能和进化的优势，这种逻辑设计相比，简单或顺序的积极调控。这些优势为植物进化出如此多的花青素抑制子提供了一个合理的解释。
Anthocyanins play a variety of adaptive roles in both vegetative tissues and reproductive organs of plants. The broad functionality of these compounds requires sophisticated regulation of the anthocyanin biosynthesis pathway to allow proper localization, timing, and optimal intensity of pigment deposition. While it is well-established that the committed steps of anthocyanin biosynthesis are activated by a highly conserved MYB-bHLH-WDR (MBW) protein complex in virtually all flowering plants, anthocyanin repression seems to be achieved by a wide variety of protein and small RNA families that function in different tissue types and in response to different developmental, environmental, and hormonal cues. In this review, we survey recent progress in the identification of anthocyanin repressors and the characterization of their molecular mechanisms. We find that these seemingly very different repression modules act through a remarkably similar logic, the so-called “double negative logic”. Much of the double-negative regulation of anthocyanin production involves signal-induced degradation or sequestration of the repressors from the MBW protein complex. We discuss the functional and evolutionary advantages of this logic design compared with simple or sequential positive regulation. These advantages provide a plausible explanation to why plants have evolved so many anthocyanin repressors.
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发表时间：
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