Multivariate neuroanatomical correlates of behavioral and psychological symptoms in dementia and the moderating role of education.
Multivariate neuroanatomical correlates of behavioral and psychological symptoms in dementia and the moderating role of education.
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DOI：
10.1016/j.nicl.2020.102452
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Lee JY
中科院分区：
文献类型：
--
作者：
Kwak S;Park S;Kim J;Park S;Lee JY
痴呆的神经精神症状(NPS)包括行为异常和情绪变化。认知储备在NPS中的缓冲作用一直不清楚。使用开放获取成像研究系列(OASIS-3)数据集。典型相关分析发现NPS的多变量模式相互关联。受教育程度较高的老年人表现出最低的NPS。随着痴呆症的脑部病理进展，通常会观察到神经精神症状。行为和情感障碍是认知障碍典型症状的独特神经解剖学基础；然而，尚不清楚丰富的智力经验，如教育程度，是否可以减轻大脑结构模式对神经精神症状严重程度的影响。我们利用了开放获取成像研究系列(OASIS-3)数据集，其中包括脑结构MRI和行为症状评估。我们纳入了904名老年人，他们大多认知正常，临床诊断为非常轻到中度的阿尔茨海默病或其他类型的痴呆症。典型相关分析用于确定灰质结构与神经精神症状严重程度之间的多变量关联模式。首先，我们确定了两种典型模式，它们捕捉了神经精神症状的共同因素和情绪特定因素的不同神经解剖学基础。第一种常见模式反映杏仁核体积较小，邻近的颞叶区域厚度较大。第二种情绪模式反映了外侧和眼眶前额叶区域厚度的模式。在外部相关分析中，两种典型相关性反映了整体脑体积和脑白质损伤；然而，第二种模式与功能损害或认知功能无关。此外，受过较高教育的老年人表现出的行为症状严重程度有所减轻，即使存在大脑结构模式。我们的发现表明，教育程度作为认知储备的替代指标，可以减轻痴呆症的行为和情感症状的严重程度。
Neuropsychiatric symptoms (NPS) in dementia includes aberrant behavior and mood changes. The buffering role of cognitive reserve has been unclear in NPS. Open Access Series of Imaging Studies (OASIS-3) dataset was utilized. Canonical correlation analysis identified multivariate patterns of NPS correlate. Older adults with more educational attainment showed minimal NPS. Neuropsychiatric symptoms are commonly observed as brain pathology progresses with dementia. Behavioral and affective disturbances underly the distinct neuroanatomical basis of typical symptoms of cognitive impairment; however it remains unclear whether enriched intellectual experience, such as educational attainment, can mitigate the effect of brain structural patterns on neuropsychiatric symptom severity. We utilized the Open Access Series of Imaging Studies (OASIS-3) dataset, which includes brain structural MRI and behavioral symptom evaluation. We included 904 older adults who were mostly cognitively normal, clinically diagnosed with very mild to moderate Alzheimer’s disease, or other types of dementia. Canonical correlation analysis was used to identify the patterns of multivariate association between the gray matter structure and neuropsychiatric symptom severity. First, we identified two canonical modes capturing the distinct neuroanatomical basis of common and mood-specific factors of neuropsychiatric symptoms. The first common pattern reflected a smaller volume in the amygdala and adjacent temporal regional thickness. The second mood-specific pattern reflected patterns in lateral and orbital prefrontal regional thickness. In the external correlational analysis, the two canonical correlations reflected global brain volume and white matter lesions; however, the second pattern was not associated with functional impairments or cognitive function. Moreover, older adults with higher education showed an attenuated severity of behavioral symptoms, even with the presence of a brain structural pattern. Our findings suggest that educational attainment, as a proxy of cognitive reserve, can mitigate the severity of behavioral and affective symptoms of dementia.
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DOI：
10.3233/jad-170360
发表时间：
2017
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Franzmeier N;Hartmann JC;Taylor ANW;Araque Caballero MÁ;Simon-Vermot L;Buerger K;Kambeitz-Ilankovic LM;Ertl-Wagner B;Mueller C;Catak C;Janowitz D;Stahl R;Dichgans M;Duering M;Ewers M
通讯作者：
Ewers M
影响因子：
82.9
作者：
Drysdale AT;Grosenick L;Downar J;Dunlop K;Mansouri F;Meng Y;Fetcho RN;Zebley B;Oathes DJ;Etkin A;Schatzberg AF;Sudheimer K;Keller J;Mayberg HS;Gunning FM;Alexopoulos GS;Fox MD;Pascual-Leone A;Voss HU;Casey BJ;Dubin MJ;Liston C
通讯作者：
Liston C
影响因子：
4.2
作者：
Foubert-Samier, Alexandra;Catheline, Gwenaelle;Dartigues, Jean-Francois
通讯作者：
Dartigues, Jean-Francois
影响因子：
5.7
作者：
Habeck, Christian;Foster, Norman L.;Stern, Yaakov
通讯作者：
Stern, Yaakov
影响因子：
4.2
作者：
Arenaza-Urquijo, Eider M.;Bejanin, Alexandre;Chetelat, Gael
通讯作者：
Chetelat, Gael