Insights into discharge argon-mediated biofilm inactivation.
Insights into discharge argon-mediated biofilm inactivation.
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DOI：
10.1080/08927014.2013.832222
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发表时间：
2013
期刊：
影响因子：
2.7
通讯作者：
Liang JF
中科院分区：
文献类型：
--
作者：
Traba C;Chen L;Liang D;Azzam R;Liang JF
固液界面细菌生物膜的形成给生物医学科学带来了许多问题。传统的灭菌和净化方法不适合新型且更复杂的生物材料。本文研究了气体放电在生物材料上生物膜灭活和去除中的效率和效果。我们发现，虽然排出的氧气、氮气和氩气都表现出优异的抗菌和抗生物膜活性，但具有不同化学/物理性质的气体具有不同的作用机制。放电氧气和氮气介导的净化与强烈的蚀刻效应有关，这可能导致活细菌重新定位，从而导致污染扩散。相反，低功率放电氩气虽然保持了优异的抗菌能力，但蚀刻效果可以忽略不计。基于这些结果，建立了一种使用放电氩气的有效净化方法，其中细菌和生物膜被原位杀死，然后从受污染的生物材料中去除。这种新颖的程序适用于体内和临床环境中的各种生物材料和生物医学设备。
Formation of bacterial biofilms at solid-liquid interfaces creates numerous problems in biomedical sciences. Conventional sterilization and decontamination methods are not suitable for new and more sophisticated biomaterials. In this paper, the efficiency and effectiveness of gas discharges in inactivation and removal of biofilms on biomaterials were studied. We found that although discharge oxygen, nitrogen and argon all demonstrated excellent antibacterial and antibiofilm activity, gases with distinct chemical/physical properties underwent different mechanisms of action. Discharge oxygen and nitrogen mediated decontamination was associated with strong etching effects, which can cause live bacteria relocation and thus contamination spreading. On the contrary, although discharge argon at low powers maintained excellent antibacterial ability, it had negligible etching effects. Based on these results, an effective decontamination approach using discharge argon was established in which bacteria and biofilms were killed in situ and then removed from contaminated biomaterials. This novel procedure is applicable for a wide range of biomaterials and biomedical devices in an in vivo and clinical setting.
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影响因子：
2.8
作者：
Joaquin, Jonathan C.;Kwan, Calvin;Brelles-Marino, Graciela
通讯作者：
Brelles-Marino, Graciela
影响因子：
2.7
作者：
Traba C;Liang JF
通讯作者：
Liang JF
影响因子：
3.4
作者：
Boudam, M. K.;Moisan, M.;Massines, F.
通讯作者：
Massines, F.
影响因子：
3.4
作者：
Opretzka, J.;Benedikt, J.;von Keudell, A.
通讯作者：
von Keudell, A.
影响因子：
1.7
作者：
Sbarra, Maria S.;Arciola, Carla R.;Visai, Livia
通讯作者：
Visai, Livia