Heightened pain sensitivity in individuals with signs and symptoms of carpal tunnel syndrome and the relationship to clinical outcomes following a manual therapy intervention.
Heightened pain sensitivity in individuals with signs and symptoms of carpal tunnel syndrome and the relationship to clinical outcomes following a manual therapy intervention.
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DOI：
10.1016/j.math.2011.06.003
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发表时间：
2011-12
期刊：
影响因子：
--
通讯作者：
George, Steven Z.
中科院分区：
文献类型：
--
作者：
Bialosky, Joel E.;Bishop, Mark D.;Robinson, Michael E.;Price, Donald D.;George, Steven Z.
与减轻疼痛敏感性相关的神经生理反应是手工治疗的一种建议机制。先前的研究发现，与健康对照相比，腕管综合征（CTS）患者的疼痛阈值普遍较低。本研究试图确定在阈上测量和特定于疼痛中枢整合的测量（时间和感觉后）中是否存在类似的结果。此外，我们希望确定疼痛敏感性的测量是否与接受手工治疗干预的CTS体征和症状参与者的临床结果相关。与健康对照相比，有CTS体征和症状的个体报告对机械疼痛、时间累积和感觉后的阈上测量更敏感。机械疼痛敏感性的立即减轻和对手工治疗干预的反应以及3周手工治疗后3周时间累积的衰减与有CTS体征和症状的参与者临床疼痛强度的3周变化相关。这些发现表明，多个参数的疼痛敏感性升高可能与CTS有关。此外，机械性疼痛、感觉后疼痛和时间累积的改变可能与临床结果的改善有关。
Neurophysiological responses related to lessening of pain sensitivity are a suggested mechanism of manual therapy. Prior studies have observed generalized lower pain thresholds associated with carpal tunnel syndrome (CTS) in comparison to healthy controls. The present study sought to determine whether similar findings were present in suprathreshold measures and measures specific to central integration of pain (temporal summation and after sensations). Additionally, we wished to determine whether measures of pain sensitivity were related to clinical outcomes in participants with signs and symptoms of CTS receiving a manual therapy intervention. Individuals with signs and symptoms of CTS reported greater pain sensitivity to suprathreshold measures of mechanical pain, temporal summation, and after sensation in comparison to healthy controls. Immediate lessening of mechanical pain sensitivity and after sensations in response to a manual therapy intervention and 3- week attenuation of temporal summation following a 3- week course of manual therapy were associated with 3- week changes in clinical pain intensity in participants with signs and symptoms of CTS. These findings suggest heightened pain sensitivity across several parameters may be associated with CTS. Furthermore, changes in mechanical pain, after sensation, and temporal summation may be related to improvements in clinical outcomes.
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DOI：
10.5435/00124635-200906000-00007
发表时间：
2009-06
期刊：
The Journal of the American Academy of Orthopaedic Surgeons
影响因子：
--
作者：
Keith MW;Masear V;Chung K;Maupin K;Andary M;Amadio PC;Barth RW;Watters WC 3rd;Goldberg MJ;Haralson RH 3rd;Turkelson CM;Wies JL
通讯作者：
Wies JL
影响因子：
3.7
作者：
Rygh, LJ;Svendsen, F;Tjolsen, A
通讯作者：
Tjolsen, A
DOI：
10.1016/j.jmpt.2004.04.005
发表时间：
2004-06-01
影响因子：
1.3
作者：
Boal, RW;Gillette, RG
通讯作者：
Gillette, RG
影响因子：
7.4
作者：
Staud, R;Cannon, RC;Vierck, CJ
通讯作者：
Vierck, CJ
由有害热脉冲诱发的第 1 次疼痛的外周抑制和第 2 次疼痛的中枢传导
影响因子：
7.4
作者：
PRICE, DD;HU, JW;GRACELY, RH
通讯作者：
GRACELY, RH