Anthocyanins from Eugenia brasiliensis edible fruits as potential therapeutics for COPD treatment.
Anthocyanins from Eugenia brasiliensis edible fruits as potential therapeutics for COPD treatment.
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DOI：
10.1016/j.foodchem.2012.01.086
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发表时间：
2012-10-01
期刊：
影响因子：
8.8
通讯作者：
Kennelly, Edward J.
中科院分区：
文献类型：
--
作者：
Flores, Gema;Dastmalchi, Keyvan;Paulino, Sturlainny;Whalen, Kathleen;Dabo, Abdoulaye J.;Reynertson, Kurt A.;Foronjy, Robert F.;D'Armiento, Jeanine M.;Kennelly, Edward J.
用高效液相色谱-电感耦合等离子体质谱(LC-PDA)和液质联用(LC-MS)对巴西丁香果实中的9种花色苷(1-9)进行了鉴定，其中7种为首次报道。研究了两种主要花色苷，飞雀素(8)和花青素(9)在香烟烟雾提取物(CSE)作用前后对细胞产生趋化因子白介素8(IL-8)的抑制活性。在未处理的细胞中，浓度为0.1-10M的花青素和飞雀素处理细胞后，IL-8的量没有变化，飞雀素(8)和花青素(9)分别在1M和10M时减少了处理细胞中IL-8的产生。Delphinidin(8)呈剂量依赖性抑制CSE处理的细胞中IL-8的表达。
Nine anthocyanins (1–9) from the edible fruits of Eugenia brasiliensis were identified by HPLC-PDA and LC-MS, and seven of these are described for the first time in this Brazilian fruit. Two of the major anthocyanins, delphinidin (8) and cyanidin (9), were studied for their inhibitory activity against chemokine interleukin-8 (IL-8) production before and after cigarette smoke extract (CSE) treatment of cells. In non-treated cells the amount of IL-8 was unchanged following treatment with cyanidin and delphinidin in concentrations 0.1–10 M. Both delphinidin (8) and cyanidin (9) decreased the production of IL-8 in treated cells, at 1 M and 10 M, respectively. Delphinidin (8) demonstrated IL-8 inhibition in the CSE treated cells in a dose-dependent manner.
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影响因子：
3.3
作者：
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通讯作者：
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影响因子：
6.1
作者：
Dastmalchi K;Flores G;Petrova V;Pedraza-Peñalosa P;Kennelly EJ
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影响因子：
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作者：
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通讯作者：
Mateus, Nuno
影响因子：
8
作者：
De Diego Damia, Alfredo;Cortijo Gimeno, Julio;Milara Paya, Javier
通讯作者：
Milara Paya, Javier