Plasma fibrinogen and its correlates in elderly Japanese men living in Japan and Hawaii.

Plasma fibrinogen and its correlates in elderly Japanese men living in Japan and Hawaii.
复制标题

居住在日本和夏威夷的日本老年男性的血浆纤维蛋白原及其相关因素。

DOI:
10.1016/s0895-4356(99)00095-5
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发表时间:
1999
影响因子:
7.2
通讯作者:
Kusumi,S
Kusumi,S
中科院分区:
医学2区
文献类型:
--
作者:
Yano,K;Kodama,K;Shimizu,Y;Chyou,PH;Sharp,DS;Tracy,RP;Rodriguez,BL;Curb,JD;Kusumi,S

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使用可比方法测定了广岛日本329名男性和夏威夷檀香山3571名日裔美国男性71-93岁的血浆纤维蛋白原水平。日裔美国男性的年龄校正平均纤维蛋白原水平(307 mg/dl)显著高于日本本土男性(270 mg/dl)(p < 0.0001)。在多元线性回归模型中,纤维蛋白原水平与白色血细胞计数(WBC)和总胆固醇显著正相关,与HDL胆固醇和红细胞压积呈负相关。WBC与纤维蛋白原的相关性最强,并且这种相关性不是通过吸烟介导的。观察到的纤维蛋白原水平差异不能完全由WBC、总胆固醇和HDL胆固醇、甘油三酯、红细胞压积、体重指数和糖尿病解释。一些未测量的环境或生活方式变量,如饮食和体育活动可能是部分负责观察到的差异,在夏威夷的日本本土男性和日裔美国男性之间的纤维蛋白原水平。
Plasma fibrinogen levels were determined using comparable methods for 329 Japanese men in Hiroshima Japan, and 3571 Japanese-American men in Honolulu Hawaii, aged 71–93 years. The age-adjusted mean fibrinogen level in Japanese-American men (307 mg/dl) was significantly higher (p < 0.0001) than in native Japanese men (270 mg/dl). In multiple linear regression models, the fibrinogen level was associated significantly and positively with white blood cell count (WBC) and total cholesterol, and inversely with HDL cholesterol and hematocrit in both study samples. The strongest association with fibrinogen was shown for WBC, and this association was not mediated through cigarette smoking. The observed difference in fibrinogen levels could not be fully explained by WBC, total and HDL cholesterol, triglyceride, hematocrit, body mass index, and diabetes. Some unmeasured environmental or lifestyle variables such as diet and physical activity may be partly responsible for the observed difference in fibrinogen levels between native Japanese men and Japanese-American men in Hawaii.
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