Cross-sectional and longitudinal voxel-based grey matter asymmetries in Huntington's disease.
Cross-sectional and longitudinal voxel-based grey matter asymmetries in Huntington's disease.
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DOI：
10.1016/j.nicl.2017.10.023
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
TRACK-HD Investigators
中科院分区：
文献类型：
--
作者：
Minkova L;Gregory S;Scahill RI;Abdulkadir A;Kaller CP;Peter J;Long JD;Stout JC;Reilmann R;Roos RA;Durr A;Leavitt BR;Tabrizi SJ;Klöppel S;TRACK-HD Investigators
亨廷顿氏病（HD）是一种进行性神经退行性疾病，可以在临床发病前几十年确定地通过遗传学证实。这使得研究功能和结构的变化在HD许多年前的疾病发作，这可能会揭示重要的机械见解大脑功能，结构和组织一般。虽然局部萎缩存在于HD的早期阶段，但尚不清楚两个半球是否同样受到神经变性的影响，以及不对称的程度如何影响特定领域的功能下降。在这里，我们使用全脑体素为基础的分析，以调查横截面和纵向半球的灰质（GM）体积的不对称性，在56个显性HD（mHD），83个前显性HD（preHD），和80个健康对照（HC）。此外，使用回归分析来评估神经解剖学不对称与整个疾病谱中运动和认知测量下降之间的关系。横断面分析显示，相对于HC，mHD患者的纹状体向左偏GM萎缩，而preHD患者则无此现象。在纵向上，没有发现任何一组GM不对称性的36个月净变化。在回归分析中，HD相关的定量运动（Q-Motor）表现下降与左侧上级顶叶皮质的GM体积降低有关。这些发现表明，针对左半球的疾病影响更强，特别是在运动表现下降的患者中。这种效应在三年内没有改变，可能表明右半球的代偿作用与最近的功能成像研究一致。首次访视时，明显HD患者发现左侧纹状体灰质体积减少。36-个月的数据没有提供证据证明HD中GM偏侧化的转变。HD患者运动功能下降与左顶叶GM丢失增加有关。
Huntington's disease (HD) is a progressive neurodegenerative disorder that can be genetically confirmed with certainty decades before clinical onset. This allows the investigation of functional and structural changes in HD many years prior to disease onset, which may reveal important mechanistic insights into brain function, structure and organization in general. While regional atrophy is present at early stages of HD, it is still unclear if both hemispheres are equally affected by neurodegeneration and how the extent of asymmetry affects domain-specific functional decline. Here, we used whole-brain voxel-based analysis to investigate cross-sectional and longitudinal hemispheric asymmetries in grey matter (GM) volume in 56 manifest HD (mHD), 83 pre-manifest HD (preHD), and 80 healthy controls (HC). Furthermore, a regression analysis was used to assess the relationship between neuroanatomical asymmetries and decline in motor and cognitive measures across the disease spectrum. The cross-sectional analysis showed striatal leftward-biased GM atrophy in mHD, but not in preHD, relative to HC. Longitudinally, no net 36-month change in GM asymmetries was found in any of the groups. In the regression analysis, HD-related decline in quantitative-motor (Q-Motor) performance was linked to lower GM volume in the left superior parietal cortex. These findings suggest a stronger disease effect targeting the left hemisphere, especially in those with declining motor performance. This effect did not change over a period of three years and may indicate a compensatory role of the right hemisphere in line with recent functional imaging studies. Reduced grey matter volume in left striatum was found in manifest HD at first visit. 36-month data did not provide evidence for a shift in GM lateralization in HD. Decline in motor performance in HD was linked to increased left parietal GM loss.
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影响因子：
8.6
作者：
Reilmann, Ralf;Rouzade-Dominguez, Marie-Laure;Gomez-Mancilla, Baltazar
通讯作者：
Gomez-Mancilla, Baltazar
影响因子：
2.6
作者：
Johnson, Eileanoir B.;Rees, Elin M.;Scahill, Rachael I.
通讯作者：
Scahill, Rachael I.
影响因子：
5.3
作者：
McColgan P;Gregory S;Razi A;Seunarine KK;Gargouri F;Durr A;Roos RA;Leavitt BR;Scahill RI;Clark CA;Tabrizi SJ;Rees G;Track On‐HD Investigators;Coleman A;Decolongon J;Fan M;Petkau T;Jauffret C;Justo D;Lehericy S;Nigaud K;Valabrègue R;Choonderbeek A;Hart EP;Hensman Moss DJ;Crawford H;Johnson E;Papoutsi M;Berna C;Reilmann R;Weber N;Stout J;Labuschagne I;Landwehrmeyer B;Orth M;Johnson H
通讯作者：
Johnson H
影响因子：
--
作者：
Apostolova, Liana G.;Steiner, Calen A.;Thompson, Paul M.
通讯作者：
Thompson, Paul M.
影响因子：
14.5
作者：
Rosas, H. Diana;Salat, David H.;Hersch, Steven M.
通讯作者：
Hersch, Steven M.