Regulation of fibrinolysis in aortic surgery.
Regulation of fibrinolysis in aortic surgery.
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主动脉手术中纤维蛋白溶解的调节。
DOI：
10.1067/mva.1988.avs0080384
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发表时间：
1988
影响因子：
4.3
通讯作者：
Goldman,MH
中科院分区：
文献类型：
--
作者：
Gomez,MJ;Carroll,RC;Hansard,MR;Kidd,M;Goldman,MH
纤溶酶原激活物抑制剂的存在在纤溶调节和术后血栓形成中起重要作用。血小板和内皮细胞是纤溶酶原激活物抑制剂（派）的来源。本研究确定了血小板释放的派对围手术期纤溶停止的贡献。测定25例主动脉手术患者血浆派水平。在9例患者中，血小板释放派的贡献是通过用佛波酯-肉豆蔻酸酯乙酸酯（PMA）体外激活血小板来确定的。平均术前派水平（3.78 ± 1.19 U/ml）与对照组（3.01 ± 1.04 U/ml）相似（p> 0.05）。血浆派在手术后8小时增加至最大值，并在术后第二天恢复至术前值。在接受体外活化研究的9例患者中，PMA诱导后术前派水平（4.0 ± 0.9 U/ml）升高至5.1 ± 0.7 U/ml（p= 0.001）。血小板颗粒含量的最大刺激释放（血小板释放物）仅增加1.0 U/ml，而术后增加2.3 U/ml。术后平均峰值血浆派（6.3 ± 0.4 U/ml）不能通过诱导释放（6.3 ± 0.4 U/ml）进一步升高（p= 0.003）。主动脉手术患者术后派显著升高。派的血小板可释放池参与了术后PAI的增加，并在功能上衰竭。术后派的升高是单独体外血小板刺激的2倍。围手术期派的增加部分归因于血小板释放。（J VASCSurg1988;8：384-8.）
The existence of inhibitors of plasminogen activator has been shown to play an important role in regulation of fibrinolysis and postoperative thrombosis. Platelets and endothelium are sources of plasminogen activator inhibitor (PAI). This study determines the contribution of platelet-released PAI to perioperative fibrinolytic shutdown. PAI levels were measured in 25 patients having aortic surgery. In nine patients the platelet-released PAI contribution was determined by in vitro activation of platelets with phorbol-myristateacetate (PMA). Mean preoperative PAI levels (3.78 ± 1.19 U/ml) were similar to controls (3.01 ± 1.04 U/ml) (p> 0.05). Plasma PAI showed an operative increase to a maximum at 8 hours postoperatively and returning to preoperative values by the second postoperative day. In the nine patients who were subjected to studies with in vitro activation, the preoperative PAI level (4.0 ± 0.9 U/ml) was elevated to 5.1 ± 0.7 U/ml (p= 0.001) with PMA induction. Maximum stimulated release of platelet granule contents (platelet releasate) could account for an increase of only 1.0 U/ml compared with a postoperative increase of 2.3 U/ml. Postoperative mean peak plasma PAI (6.3 ± 0.4 U/ml) could not be further elevated by induced release (6.3 ± 0.4 U/ml) (p= 0.003). A statistically significant increase in PAI occurred in aortic surgery patients postoperatively. The platelet releasable pool of PAI contributed to the increase and was functionally exhausted postoperatively. Postoperative increases of PAI were twice that induced by platelet in vitro stimulation alone. The perioperative increase in PAI was partly due to platelet release. (J VASCSURG1988;8:384-8.)
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围手术期纤溶动力学。
DOI：
--
发表时间：
1987
期刊：
Current Surgery
影响因子：
--
作者：
M. J. Gómez;R. Carroll;R. Hansard;M. Goldman
通讯作者：
M. Goldman
组织型纤溶酶原激活剂及其速效抑制剂血浆水平的术后变化 - 与深静脉血栓形成的关系及预防的影响
影响因子：
6.7
作者：
J. Paramo;M. Alfaro;E. Rocha
通讯作者：
E. Rocha
DOI：
10.1016/j.bbrc.2014.10.050
发表时间：
2014-11-07
影响因子：
3.1
作者：
Fujiwara, Tohru;Okamoto, Koji;Harigae, Hideo
通讯作者：
Harigae, Hideo
人血小板释放纤溶酶原激活剂抑制剂的研究
影响因子：
6.7
作者：
E. Kruithof;C. Tran;F. Bachmann
通讯作者：
F. Bachmann
血小板纤溶酶原激活剂抑制剂：人血液中两种不同的内皮细胞型纤溶酶原激活剂抑制剂池
影响因子：
6.7
作者：
E. Sprengers;J. Akkerman;B. G. Jansen
通讯作者：
B. G. Jansen