Serial interval and incubation period of COVID-19: a systematic review and meta-analysis.
Serial interval and incubation period of COVID-19: a systematic review and meta-analysis.
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DOI：
10.1186/s12879-021-05950-x
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发表时间：
2021-03-11
影响因子：
3.7
通讯作者：
Birhan TY
中科院分区：
文献类型：
--
作者：
Alene M;Yismaw L;Assemie MA;Ketema DB;Gietaneh W;Birhan TY
了解决定COVID-19传播动态的流行病学参数对于公共卫生干预至关重要。在全球范围内，开展了多项研究，以估计COVID-19的平均连续间隔和潜伏期。结合估计COVID-19平均序列间隔和潜伏期的现有研究结果，可显着提高证据质量。因此，本研究旨在确定COVID-19的总体平均序列间隔和潜伏期。我们遵循PRISMA检查表来介绍这项研究。在2020年6月1日至7月31日期间，由两位经验丰富的评审（MAA和DBK）作者从国际电子数据库（b谷歌Scholar、PubMed、Science Direct、Web of Science、CINAHL和Cochrane Library）中进行了全面的检索策略。所有报告COVID-19确诊患者的连续间隔或潜伏期的观察性研究均纳入本研究。采用I2和Higgins检验评估各研究的异质性。采用适用于横断面研究的NOS来评价研究的质量。采用随机效应meta分析确定合并估计值，CI为95%。使用Microsoft Excel进行数据提取，R软件进行分析。我们总共结合了23项研究来估计COVID-19的总体平均序列间隔。COVID-19的平均连续时间间隔为4。2至7.5天。我们的荟萃分析显示，COVID-19的加权合并平均序列间隔为5.2天（95%CI: 4.9-5.5）。此外，为了汇总COVID-19的平均潜伏期，我们纳入了14篇文章。COVID-19的平均潜伏期也在4.8天至9天之间。据此，COVID-19加权合并平均潜伏期为6.5天（95%CI: 5.9 ~ 7.1）。本系统综述和荟萃分析显示，COVID-19的加权合并平均序列间隔和潜伏期分别为5.2天和6.5天。在本研究中，COVID-19的平均连续间隔时间短于平均潜伏期，这表明大量的COVID-19病例将归因于症状前传播。在线版本包含补充材料，可在10.1186/s12879-021-05950-x获得。
Understanding the epidemiological parameters that determine the transmission dynamics of COVID-19 is essential for public health intervention. Globally, a number of studies were conducted to estimate the average serial interval and incubation period of COVID-19. Combining findings of existing studies that estimate the average serial interval and incubation period of COVID-19 significantly improves the quality of evidence. Hence, this study aimed to determine the overall average serial interval and incubation period of COVID-19. We followed the PRISMA checklist to present this study. A comprehensive search strategy was carried out from international electronic databases (Google Scholar, PubMed, Science Direct, Web of Science, CINAHL, and Cochrane Library) by two experienced reviewers (MAA and DBK) authors between the 1st of June and the 31st of July 2020. All observational studies either reporting the serial interval or incubation period in persons diagnosed with COVID-19 were included in this study. Heterogeneity across studies was assessed using the I2 and Higgins test. The NOS adapted for cross-sectional studies was used to evaluate the quality of studies. A random effect Meta-analysis was employed to determine the pooled estimate with 95% (CI). Microsoft Excel was used for data extraction and R software was used for analysis. We combined a total of 23 studies to estimate the overall mean serial interval of COVID-19. The mean serial interval of COVID-19 ranged from 4. 2 to 7.5 days. Our meta-analysis showed that the weighted pooled mean serial interval of COVID-19 was 5.2 (95%CI: 4.9–5.5) days. Additionally, to pool the mean incubation period of COVID-19, we included 14 articles. The mean incubation period of COVID-19 also ranged from 4.8 to 9 days. Accordingly, the weighted pooled mean incubation period of COVID-19 was 6.5 (95%CI: 5.9–7.1) days. This systematic review and meta-analysis showed that the weighted pooled mean serial interval and incubation period of COVID-19 were 5.2, and 6.5 days, respectively. In this study, the average serial interval of COVID-19 is shorter than the average incubation period, which suggests that substantial numbers of COVID-19 cases will be attributed to presymptomatic transmission. The online version contains supplementary material available at 10.1186/s12879-021-05950-x.
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影响因子：
158.5
作者：
Li, Qun;Guan, Xuhua;Feng, Zijian
通讯作者：
Feng, Zijian
影响因子：
4.5
作者：
Park JE;Jung S;Kim A;Park JE
通讯作者：
Park JE
影响因子：
56.3
作者：
Cauchemez, Simon;Fraser, Christophe;Van Kerkhove, Maria D.;Donnelly, Christi A.;Riley, Steven;Rambaut, Andrew;Enouf, Vincent;van der Werf, Sylvie;Ferguson, Neil M.
通讯作者：
Ferguson, Neil M.
影响因子：
56.9
作者：
Lipsitch, M;Cohen, T;Murray, M
通讯作者：
Murray, M
DOI：
10.1016/s0140-6736(03)13410-1
发表时间：
2003-05-24
期刊：
Lancet (London, England)
影响因子：
--
作者：
Donnelly CA;Ghani AC;Leung GM;Hedley AJ;Fraser C;Riley S;Abu-Raddad LJ;Ho LM;Thach TQ;Chau P;Chan KP;Lam TH;Tse LY;Tsang T;Liu SH;Kong JH;Lau EM;Ferguson NM;Anderson RM
通讯作者：
Anderson RM