The effect of prolonged spaceflight on cerebrospinal fluid and perivascular spaces of astronauts and cosmonauts.
The effect of prolonged spaceflight on cerebrospinal fluid and perivascular spaces of astronauts and cosmonauts.
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DOI：
10.1073/pnas.2120439119
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发表时间：
2022-04-26
影响因子：
11.1
通讯作者：
Wuyts, Floris L.
中科院分区：
文献类型：
--
作者：
Barisano, Giuseppe;Sepehrband, Farshid;Collins, Heather R.;Jillings, Steven;Jeurissen, Ben;Taylor, James A.;Schoenmaekers, Catho;De laet, Chloe;Rukavishnikov, Ilya;Nosikova, Inna;Litvinova, Liudmila;Rumshiskaya, Alena;Annen, Jitka;Sijbers, Jan;Laureys, Steven;Van Ombergen, Angelique;Petrovichev, Victor;Sinitsyn, Valentin;Pechenkova, Ekaterina;Grishin, Alexey;zu Eulenburg, Peter;Lawl, Meng;Sunaert, Stefan;Parizel, Paul M.;Tomilovskaya, Elena;Roberts, Donna R.;Wuyts, Floris L.
长时间的航天飞行引起大脑和脑脊液隔室的变化和称为航天相关神经-眼综合征的视力问题。这些变化的临床意义以及它们是否同样影响不同空间机构的工作人员仍然未知。我们使用MRI分析了在国际空间站（ISS）进行6个月的太空飞行后，美国宇航局（NASA）、欧洲航天局（esa）和俄罗斯航天局（Roscosmos）宇航员血管周围空间（PVS）发生的变化。我们发现，在太空飞行后，基底神经节PVS和白质PVS （WM-PVS）的体积增加，这在美国宇航局（NASA）的宇航员中比在俄罗斯航天局（Roscosmos）的宇航员中更为突出。此外，两组患者均表现出相似程度的侧脑室增大和蛛网膜下腔空间减少，这与WM-PVS增大有关。由于所有机组人员在国际空间站上都经历了相同的环境，wm - pv扩大的差异可能是由于其他因素造成的，其中包括使用对策和高阻力运动制度的差异，这可能会影响脑液的再分配。此外，与未受影响的宇航员相比，患有SANS的NASA宇航员在飞行前和飞行后的wm - pv体积都更大。这些结果为wm - pv流体与SANS之间的潜在联系提供了证据。
Long-duration spaceflight induces changes to the brain and cerebrospinal fluid compartments and visual acuity problems known as spaceflight-associated neuro-ocular syndrome (SANS). The clinical relevance of these changes and whether they equally affect crews of different space agencies remain unknown. We used MRI to analyze the alterations occurring in the perivascular spaces (PVS) in NASA and European Space Agency astronauts and Roscosmos cosmonauts after a 6-mo spaceflight on the International Space Station (ISS). We found increased volume of basal ganglia PVS and white matter PVS (WM-PVS) after spaceflight, which was more prominent in the NASA crew than the Roscosmos crew. Moreover, both crews demonstrated a similar degree of lateral ventricle enlargement and decreased subarachnoid space at the vertex, which was correlated with WM-PVS enlargement. As all crews experienced the same environment aboard the ISS, the differences in WM-PVS enlargement may have been due to, among other factors, differences in the use of countermeasures and high-resistive exercise regimes, which can influence brain fluid redistribution. Moreover, NASA astronauts who developed SANS had greater pre- and postflight WM-PVS volumes than those unaffected. These results provide evidence for a potential link between WM-PVS fluid and SANS.
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影响因子：
4.6
作者：
Sepehrband, Farshid;Barisano, Giuseppe;Toga, Arthur W.
通讯作者：
Toga, Arthur W.
影响因子：
--
作者：
Bogomolov, V. V.;Kuzmin, M. P.;Danilichev, S. N.
通讯作者：
Danilichev, S. N.
影响因子：
19.7
作者：
Kramer, Larry A.;Hasan, Khader M.;Macias, Brandon R.
通讯作者：
Macias, Brandon R.
影响因子：
158.5
作者：
Roberts, Donna R.;Albrecht, Moritz H.;Antonucci, Michael U.
通讯作者：
Antonucci, Michael U.
DOI：
10.1097/jom.0000000000000158
发表时间：
2014-05-01
影响因子：
3.2
作者：
Law, Jennifer;Van Baalen, Mary;Alexander, David
通讯作者：
Alexander, David