Prenatal sex hormones and behavioral outcomes in children.
Prenatal sex hormones and behavioral outcomes in children.
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DOI：
10.1016/j.psyneuen.2019.104547
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发表时间：
2020-03
影响因子：
3.7
通讯作者：
TIDES Study team
中科院分区：
文献类型：
--
作者：
Day DB;Collett BR;Barrett ES;Bush NR;Swan SH;Wang C;Sathyanarayana S;TIDES Study team
子宫内异常的性激素水平与儿童行为问题有关，但尚不清楚产前性激素的正常变化是否与儿童期的后续行为有关。我们评估了母体性激素，包括血清雌酮（E1）、雌二醇（E2）、雌三醇（E3）、游离睾酮（FT）和总睾酮（TT），妊娠早期（孕6-21周（平均= 11.1）），并在4-5岁时使用儿童行为评估系统（BASC-2）和社会反应量表（SRS-2）评估404名母亲/婴儿发育和环境研究中的儿童对（211名女孩，193名男孩），一项多中心妊娠队列研究。在两种性别组合中使用多元线性回归评价激素与综合评分之间的关联，并使用单独的模型通过添加相互作用项评估性别的效应修饰。在两种性别中，母体FT或TT增加10倍分别与BASC-2内化复合T评分高4.3分（95% CI：0.5，8.2）或4.4分（0.8，8.0）相关。此外，FT或TT增加10倍与行为症状指数综合评分增加3.8分（0.04，7.5）或4.0分（0.5，7.5）相关。在按性别评估效应修正的模型中，E1增加10倍与仅女孩适应技能综合评分下降4.3分（1.2，7.4）相关（交互作用p=0.04）。我们观察到睾酮和内化行为和行为症状指数之间的关联，在两性，以及女性特定的关联E1和适应技能。怀孕期间的性激素可能在影响晚年行为方面发挥关键作用，其他研究应进一步检查对激素信号敏感的不同时期。
Abnormal sex hormone levels in utero have been associated with child behavioral problems, but it is unclear if normal variation in prenatal sex hormones is associated with subsequent behavior in childhood. We assessed maternal sex hormones, including serum estrone (E1), estradiol (E2), estriol (E3), free testosterone (FT), and total testosterone (TT), during early pregnancy (gestational week 6–21 (mean = 11.1)) and evaluated child behavior at ages 4–5 using the Behavioral Assessment System for Children (BASC-2) and Social Responsiveness Scale (SRS-2) in 404 mother/child pairs (211 girls, 193 boys) within The Infant Development and Environment Study, a multi-site pregnancy cohort study. Associations between hormones and composite scores were evaluated using multiple linear regressions in both sexes combined, and separate models assessed effect modification by sex with the addition of interaction terms. A 10-fold increase in maternal FT or TT was associated in both sexes with a 4.3-point (95% CI: 0.5, 8.2) or 4.4-point (0.8, 8.0) higher BASC-2 internalizing composite T score, respectively. In addition, a 10-fold increase in FT or TT was associated with a 3.8-point (0.04, 7.5) or 4.0-point (0.5, 7.5) higher behavioral symptoms index composite score. In models evaluating effect modification by sex, a 10-fold increase in E1 was associated with a 4.3-point (1.2, 7.4) decrease in adaptive skills composite score in girls only (interaction p=0.04). We observed associations between testosterone and internalizing behaviors and behavioral symptoms index in both sexes, as well as a female-specific association between E1 and adaptive skills. Sex hormones during pregnancy may play a key role in influencing later-life behavior, and additional studies should further examine different periods of susceptibility to hormonal signals.
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影响因子：
3.5
作者：
Bergman, Kristin;Glover, Vivette;Sarkar, Pampa;Abbott, Dave H.;O'Connor, Thomas G.
通讯作者：
O'Connor, Thomas G.
影响因子：
4.6
作者：
Eaton NR;Keyes KM;Krueger RF;Balsis S;Skodol AE;Markon KE;Grant BF;Hasin DS
通讯作者：
Hasin DS
DOI：
10.1111/jcpp.12337
发表时间：
2015-06
期刊：
Journal of child psychology and psychiatry, and allied disciplines
影响因子：
--
作者：
Arnett AB;Pennington BF;Willcutt EG;DeFries JC;Olson RK
通讯作者：
Olson RK
影响因子：
6.9
作者：
Cesta, Carolyn E.;Oberg, Anna S.;Rosenqvist, Mina A.
通讯作者：
Rosenqvist, Mina A.
影响因子：
4.4
作者：
Drolet, Renee;Simard, Marc;Tremblay, Yves
通讯作者：
Tremblay, Yves