In utero cortisol and testosterone exposure and fear reactivity in infancy.
In utero cortisol and testosterone exposure and fear reactivity in infancy.
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DOI：
10.1016/j.yhbeh.2009.12.012
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发表时间：
2010-03
影响因子：
3.5
通讯作者：
O'Connor, Thomas G.
中科院分区：
文献类型：
--
作者：
Bergman, Kristin;Glover, Vivette;Sarkar, Pampa;Abbott, Dave H.;O'Connor, Thomas G.
胎儿程序化正在成为理解健康和疾病的发育起源，包括行为结果的一个主要概念模型。作为一项关于产前压力和儿童发育的更大规模研究的一部分，我们调查了产前激素暴露和恐惧反应之间的关联，恐惧反应是预测长期行为适应的一个气质维度。从接受临床指征羊膜穿刺术的妇女的羊水样本中收集羊水，用于以后分析皮质醇和睾酮。在17个月时召回出生结果正常的儿童进行随访评估，当时我们进行了气质观察性评估(LAB-TAB；n=108)。关于怀孕和产科结局的信息被包括在协变量中。结果表明，在男孩中，产前睾酮水平与观察到的恐惧反应显著相关(r(53)=0.34，p=0.01)；在女孩中没有发现显著的影响(r(54)=-0.07，ns)；在控制产科焦虑、心理社会焦虑和父母焦虑之后，这种影响仍然存在。胎儿皮质醇暴露和恐惧反应之间没有明显的关联。宫内睾丸素对男孩恐惧反应的预测扩展了先前关于产前睾酮的研究，可能代表了与更大的唤醒和反应能力的一般易感性有关。
Fetal programming is emerging as a major conceptual model for understanding developmental origins of health and disease, including behavioral outcomes. As part of a larger study of prenatal stress and child development, we examined the association between prenatal hormone exposure and fear reactivity, a temperament dimension that is a predictor of long-term behavioral adjustment. Amniotic fluid was collected from a sample of women undergoing clinically indicated amniocentesis for later analysis of cortisol and testosterone. Children with normal birth outcomes were recalled for follow-up assessment at 17 months, at which time we administered an observational assessment of temperament (lab-TAB; n=108). Information on pregnancy and obstetric outcome was included as covariates. Results indicated that there was a significant association between prenatal testosterone and observed fear reactivity in boys (r(53)=0.34, p=0.01); no significant effect was found in girls (r(54)=-.07, ns); the effect remained when obstetric, psychosocial, and parental anxiety were controlled for. There was not a significant association between fetal cortisol exposure and fear reactivity. The prediction from in utero testosterone exposure to fear reactivity in boys extends prior research on prenatal testosterone, and may represent an association with a general predisposition to greater arousal and reactivity.
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1111/j.1469-7610.2008.01987.x
发表时间：
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作者：
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DOI：
10.1097/chi.0b013e31814a62f6
发表时间：
2007-11-01
影响因子：
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作者：
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通讯作者：
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