Spleen vagal denervation inhibits the production of antibodies to circulating antigens.
Spleen vagal denervation inhibits the production of antibodies to circulating antigens.
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DOI：
10.1371/journal.pone.0003152
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发表时间：
2008-09-05
期刊：
影响因子：
3.7
通讯作者：
Escobar C
中科院分区：
文献类型：
--
作者：
Buijs RM;van der Vliet J;Garidou ML;Huitinga I;Escobar C
最近，中枢神经系统的迷走神经输出被证明抑制了对病原体的先天免疫防御。在这里，我们用解剖学和生理学技术研究了脑与脾的联系，并提供了证据，证明大脑有能力通过副交感自主神经输出刺激抗原特异性抗体的产生。结果表明：1.脾不仅接受交感神经传入，还接受副交感神经传入。2.静脉注射三硝基苯基卵清蛋白(TNP-OVA)不会激活大脑，也不会诱导免疫反应。3.静脉注射含有炎症诱导剂的TNP-OVA；脂多糖(LPS)，激活大脑并诱导TNP特异性IgM。4.内毒素激活的神经元与向脾提供副交感自主神经信息的神经元位于大脑的同一区域，这表明大脑和免疫系统之间存在反馈电路。因此，我们研究了脑与脾的相互作用，观察到脾的特异性副交感神经去神经而不是交感神经去神经可以消除内毒素诱导的对TNP-OVA的抗体反应。这些发现不仅表明大脑可以通过自主神经输出刺激抗体产生，还表明内毒素作为佐剂刺激抗体产生的能力可能还取决于其激活大脑的能力。自主神经系统在刺激适应性免疫反应中的作用可能解释了为什么情绪和睡眠会影响抗体的产生。
Recently the vagal output of the central nervous system has been shown to suppress the innate immune defense to pathogens. Here we investigated by anatomical and physiological techniques the communication of the brain with the spleen and provided evidence that the brain has the capacity to stimulate the production of antigen specific antibodies by its parasympathetic autonomic output. This conclusion was reached by successively demonstrating that: 1. The spleen receives not only sympathetic input but also parasympathetic input. 2. Intravenous trinitrophenyl-ovalbumin (TNP-OVA) does not activate the brain and does not induce an immune response. 3. Intravenous TNP-OVA with an inducer of inflammation; lipopolysaccharide (LPS), activates the brain and induces TNP-specific IgM. 4. LPS activated neurons are in the same areas of the brain as those that provide parasympathetic autonomic information to the spleen, suggesting a feed back circuit between brain and immune system. Consequently we investigated the interaction of the brain with the spleen and observed that specific parasympathetic denervation but not sympathetic denervation of the spleen eliminates the LPS-induced antibody response to TNP-OVA. These findings not only show that the brain can stimulate antibody production by its autonomic output, it also suggests that the power of LPS as adjuvant to stimulate antibody production may also depend on its capacity to activate the brain. The role of the autonomic nervous system in the stimulation of the adaptive immune response may explain why mood and sleep have an influence on antibody production.
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DOI：
10.1073/pnas.0504365102
发表时间：
2005-09-13
影响因子：
11.1
作者：
Rosenkranz, MA;Busse, WW;Davidson, RJ
通讯作者：
Davidson, RJ
DOI：
10.1073/pnas.0600506103
发表时间：
2006-03-28
影响因子：
11.1
作者：
Pavlov, VA;Ochani, M;Tracey, KJ
通讯作者：
Tracey, KJ
影响因子：
15.9
作者：
Kreier, F;Fliers, E;Buijs, RM
通讯作者：
Buijs, RM
DOI：
10.1073/pnas.1534743100
发表时间：
2003-09-16
影响因子：
11.1
作者：
Rosenkranz, MA;Jackson, DC;Davidson, RJ
通讯作者：
Davidson, RJ
影响因子：
4.8
作者：
Laflamme, N;Rivest, S
通讯作者：
Rivest, S